TY  - JOUR
AU  - Preßler, Hannah
AU  - Haddy, Imène
AU  - Daugherty, Claire
AU  - Postila, Ville
AU  - Meisel, Andreas
TI  - Paraneoplastic Lambert-Eaton myasthenic syndrome associated with non-small cell lung cancer: data from the European LEMS registry and systematic review.
JO  - Neurological research and practice
VL  - 7
IS  - 1
SN  - 2524-3489
CY  - [London]
PB  - BioMed Central
M1  - DZNE-2025-01362
SP  - 95
PY  - 2025
AB  - Paraneoplastic Lambert-Eaton myasthenic syndrome (pLEMS) is well-established in small-cell lung cancer (SCLC), but data on other malignancies are limited. We aimed to define the clinical phenotype of pLEMS in non-SCLC cancers (non-SCLC-pLEMS) relative to SCLC-associated LEMS (SCLC-pLEMS) and autoimmune LEMS (aiLEMS).Retrospective analysis was conducted to compare patients with SCLC-pLEMS, aiLEMS and non-SCLC-pLEMS from the European LEMS registry, and further non-SCLC-pLEMS cases were identified by a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.The registry included 72 aiLEMS, 12 SCLC-pLEMS, and 11 non-SCLC-pLEMS patients. LEMS preceded cancer diagnosis in 33
KW  - Ataxia (Other)
KW  - Cancer treatment (Other)
KW  - Lambert-Eaton myasthenic syndrome (Other)
KW  - Paraneoplastic (Other)
KW  - Tumor (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41361909
C2  - pmc:PMC12687528
DO  - DOI:10.1186/s42466-025-00453-5
UR  - https://pub.dzne.de/record/282604
ER  -