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@ARTICLE{Teipel:282605,
      author       = {Teipel, Stefan and Akmatov, Manas and Michalowsky, Bernhard
                      and Junghanss, Christian and Holstiege, Jakob and Bohlken,
                      Jens},
      title        = {{A}ssociation of cancer with neuropathological markers of
                      {A}lzheimer's disease and related dementias.},
      journal      = {Alzheimer's $\&$ dementia / Diagnosis, assessment $\&$
                      disease monitoring},
      volume       = {17},
      number       = {4},
      issn         = {2352-8729},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2025-01363},
      pages        = {e70222},
      year         = {2025},
      abstract     = {We assessed associations of cancer diagnoses with
                      neuropathology of Alzheimer's disease (AD) and related
                      dementias.We retrieved 2288 cases from the National
                      Alzheimer Coordinating Center (NACC) cohort with available
                      information on cancer diagnoses and neuropathological
                      scoring of Braak stages, Thal amyloid phases, neuritic
                      plaques, TDP-43 pathology, and Lewy body pathology. We used
                      Bayesian ordinal regression to assess associations of
                      prevalent or incident cancer diagnoses with global cognition
                      and postmortem neuropathological scores.We found extreme
                      evidence (Bayes factor [BF] > 2000) that both prevalent and
                      incident cancer diagnoses were associated with better global
                      cognition, strong evidence (BF = 26) for an association of a
                      prevalent cancer diagnosis with lower TDP-43 pathology, and
                      weak evidence (BF = 3.2) for an association with lower Lewy
                      body pathology.Our data suggest that selective survival and
                      biological effects may contribute to the lower risk of
                      dementia in people with a cancer diagnosis.A prevalent
                      diagnosis of cancer was associated with a lower risk of
                      cognitive decline in older individuals.A prevalent diagnosis
                      of cancer was associated with a lower risk of TDP-43
                      pathology and Lewy body pathology in older
                      individuals.Effects of cancer on TDP-43 pathology were
                      maintained when controlling for degree of cognitive
                      decline.},
      keywords     = {Alzheimer's disease pathology (Other) / Braak stages
                      (Other) / TDP‐43 pathology (Other) / protective factor
                      (Other)},
      cin          = {AG Teipel / AG Michalowsky},
      ddc          = {610},
      cid          = {I:(DE-2719)1510100 / I:(DE-2719)5000067},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41367891},
      pmc          = {pmc:PMC12682591},
      doi          = {10.1002/dad2.70222},
      url          = {https://pub.dzne.de/record/282605},
}