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000282628 0247_ $$2doi$$a10.1016/j.semperi.2025.152128
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000282628 037__ $$aDZNE-2025-01364
000282628 041__ $$aEnglish
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000282628 1001_ $$0P:(DE-2719)9000732$$aSabir, Hemmen$$b0$$eLast author$$udzne
000282628 245__ $$aNeuroprotective therapies for neonatal hypoxic-ischemic brain injury - a contemporary update.
000282628 260__ $$aPhiladelphia, Pa.$$bSaunders$$c2025
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000282628 520__ $$aNeonatal encephalopathy of hypoxic-ischemic origin remains a leading cause of global neonatal mortality. Over the past decades, various neuroprotective strategies have been explored; however, therapeutic hypothermia remains the only clinically approved intervention to date. This review outlines emerging and adjunctive treatment modalities beyond therapeutic hypothermia and emphasizes the critical need for robust and reproducible translational research to bridge the gap between preclinical findings and clinical applications.
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000282628 650_7 $$2Other$$aHypoxic-ischemic encephalopathy (HIE)
000282628 650_7 $$2Other$$aNeuroprotection
000282628 650_7 $$2Other$$aNewborn
000282628 650_7 $$2NLM Chemicals$$aNeuroprotective Agents
000282628 650_2 $$2MeSH$$aHumans
000282628 650_2 $$2MeSH$$aHypoxia-Ischemia, Brain: therapy
000282628 650_2 $$2MeSH$$aInfant, Newborn
000282628 650_2 $$2MeSH$$aHypothermia, Induced: methods
000282628 650_2 $$2MeSH$$aNeuroprotective Agents: therapeutic use
000282628 650_2 $$2MeSH$$aNeuroprotection
000282628 650_2 $$2MeSH$$aAsphyxia Neonatorum: therapy
000282628 650_2 $$2MeSH$$aAsphyxia Neonatorum: complications
000282628 773__ $$0PERI:(DE-600)2174573-0$$a10.1016/j.semperi.2025.152128$$gVol. 49, no. 8, p. 152128 -$$n8$$p152128 -$$tSeminars in perinatology$$v49$$x0146-0005$$y2025
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