TY  - JOUR
AU  - Sabir, Hemmen
TI  - Neuroprotective therapies for neonatal hypoxic-ischemic brain injury - a contemporary update.
JO  - Seminars in perinatology
VL  - 49
IS  - 8
SN  - 0146-0005
CY  - Philadelphia, Pa.
PB  - Saunders
M1  - DZNE-2025-01364
SP  - 152128 -
PY  - 2025
AB  - Neonatal encephalopathy of hypoxic-ischemic origin remains a leading cause of global neonatal mortality. Over the past decades, various neuroprotective strategies have been explored; however, therapeutic hypothermia remains the only clinically approved intervention to date. This review outlines emerging and adjunctive treatment modalities beyond therapeutic hypothermia and emphasizes the critical need for robust and reproducible translational research to bridge the gap between preclinical findings and clinical applications.
KW  - Humans
KW  - Hypoxia-Ischemia, Brain: therapy
KW  - Infant, Newborn
KW  - Hypothermia, Induced: methods
KW  - Neuroprotective Agents: therapeutic use
KW  - Neuroprotection
KW  - Asphyxia Neonatorum: therapy
KW  - Asphyxia Neonatorum: complications
KW  - Hypoxic-ischemic encephalopathy (HIE) (Other)
KW  - Neuroprotection (Other)
KW  - Newborn (Other)
KW  - Neuroprotective Agents (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40887401
DO  - DOI:10.1016/j.semperi.2025.152128
UR  - https://pub.dzne.de/record/282628
ER  -