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000282907 0247_ $$2doi$$a10.1016/j.clinph.2025.2111405
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000282907 0247_ $$2ISSN$$a1872-8952
000282907 037__ $$aDZNE-2025-01368
000282907 041__ $$aEnglish
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000282907 1001_ $$aMaas, Roderick P P W M$$b0
000282907 245__ $$aCerebellar transcranial direct current stimulation in spinocerebellar ataxia type 3: An electric field modelling study.
000282907 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2026
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000282907 520__ $$aTo compare cerebellar transcranial direct current stimulation (tDCS)-induced electric field strengths between individuals with spinocerebellar ataxia type 3 (SCA3) and healthy controls and to identify factors that underlie the variability in field strength.MRI scans from 68 SCA3 mutation carriers spanning the disease spectrum and 37 healthy adults were used to reconstruct tetrahedral volume meshes of the head. Electric field simulations of midline cerebellar tDCS were performed with the buccinator muscle, frontopolar region, and lower neck as reference electrode positions. Eight regions of interest were defined throughout the cerebellum.Simulated electric field strengths induced by cerebellar tDCS were generally lower in SCA3 mutation carriers than in healthy controls, particularly in the anterior lobe and with cephalic reference electrodes. The frontopolar montage induced the highest field strengths, while the lower neck montage caused the lowest field strengths. Skin-cerebellum distance, Scale for the Assessment and Rating of Ataxia (SARA) score, and 'occipital angle' were independently associated with electric field strength.Skin-cerebellum distance, posterior fossa morphometry, ataxia severity, and electrode montage predict cerebellar tDCS-induced electric field strength in SCA3 mutation carriers. These results may guide the development of personalized neuromodulation protocols and inform the design of future cerebellar tDCS trials in degenerative ataxias.This study identified clinical and anatomical factors that affect cerebellar tDCS-induced field strength in individuals with the most common type of dominantly inherited ataxia worldwide.
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000282907 650_7 $$2Other$$aAtaxia
000282907 650_7 $$2Other$$aCerebellar tDCS
000282907 650_7 $$2Other$$aElectric fields
000282907 650_7 $$2Other$$aInterindividual variability
000282907 650_7 $$2Other$$aModelling study
000282907 650_7 $$2Other$$aSimulation
000282907 650_2 $$2MeSH$$aHumans
000282907 650_2 $$2MeSH$$aTranscranial Direct Current Stimulation: methods
000282907 650_2 $$2MeSH$$aMale
000282907 650_2 $$2MeSH$$aMachado-Joseph Disease: physiopathology
000282907 650_2 $$2MeSH$$aMachado-Joseph Disease: therapy
000282907 650_2 $$2MeSH$$aMachado-Joseph Disease: diagnostic imaging
000282907 650_2 $$2MeSH$$aMachado-Joseph Disease: genetics
000282907 650_2 $$2MeSH$$aFemale
000282907 650_2 $$2MeSH$$aAdult
000282907 650_2 $$2MeSH$$aMiddle Aged
000282907 650_2 $$2MeSH$$aCerebellum: physiopathology
000282907 650_2 $$2MeSH$$aCerebellum: diagnostic imaging
000282907 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000282907 650_2 $$2MeSH$$aAged
000282907 7001_ $$aGroup, ESMI MR Study$$b1$$eCollaboration Author
000282907 7001_ $$0P:(DE-2719)2811327$$aFaber, Jennifer$$b2$$udzne
000282907 7001_ $$avan de Warrenburg, Bart P C$$b3
000282907 7001_ $$aSchutter, Dennis J L G$$b4
000282907 773__ $$0PERI:(DE-600)1499934-1$$a10.1016/j.clinph.2025.2111405$$gVol. 181, p. 2111405 -$$p2111405$$tClinical neurophysiology$$v181$$x1388-2457$$y2026
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