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001     282907
005     20251217171018.0
024 7 _ |a 10.1016/j.clinph.2025.2111405
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024 7 _ |a pmid:41218516
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024 7 _ |a 1388-2457
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024 7 _ |a 0921-884X
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024 7 _ |a 1872-8952
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037 _ _ |a DZNE-2025-01368
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Maas, Roderick P P W M
|b 0
245 _ _ |a Cerebellar transcranial direct current stimulation in spinocerebellar ataxia type 3: An electric field modelling study.
260 _ _ |a Amsterdam [u.a.]
|c 2026
|b Elsevier Science
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520 _ _ |a To compare cerebellar transcranial direct current stimulation (tDCS)-induced electric field strengths between individuals with spinocerebellar ataxia type 3 (SCA3) and healthy controls and to identify factors that underlie the variability in field strength.MRI scans from 68 SCA3 mutation carriers spanning the disease spectrum and 37 healthy adults were used to reconstruct tetrahedral volume meshes of the head. Electric field simulations of midline cerebellar tDCS were performed with the buccinator muscle, frontopolar region, and lower neck as reference electrode positions. Eight regions of interest were defined throughout the cerebellum.Simulated electric field strengths induced by cerebellar tDCS were generally lower in SCA3 mutation carriers than in healthy controls, particularly in the anterior lobe and with cephalic reference electrodes. The frontopolar montage induced the highest field strengths, while the lower neck montage caused the lowest field strengths. Skin-cerebellum distance, Scale for the Assessment and Rating of Ataxia (SARA) score, and 'occipital angle' were independently associated with electric field strength.Skin-cerebellum distance, posterior fossa morphometry, ataxia severity, and electrode montage predict cerebellar tDCS-induced electric field strength in SCA3 mutation carriers. These results may guide the development of personalized neuromodulation protocols and inform the design of future cerebellar tDCS trials in degenerative ataxias.This study identified clinical and anatomical factors that affect cerebellar tDCS-induced field strength in individuals with the most common type of dominantly inherited ataxia worldwide.
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588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a Ataxia
|2 Other
650 _ 7 |a Cerebellar tDCS
|2 Other
650 _ 7 |a Electric fields
|2 Other
650 _ 7 |a Interindividual variability
|2 Other
650 _ 7 |a Modelling study
|2 Other
650 _ 7 |a Simulation
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Transcranial Direct Current Stimulation: methods
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Machado-Joseph Disease: physiopathology
|2 MeSH
650 _ 2 |a Machado-Joseph Disease: therapy
|2 MeSH
650 _ 2 |a Machado-Joseph Disease: diagnostic imaging
|2 MeSH
650 _ 2 |a Machado-Joseph Disease: genetics
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Cerebellum: physiopathology
|2 MeSH
650 _ 2 |a Cerebellum: diagnostic imaging
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
700 1 _ |a Group, ESMI MR Study
|b 1
|e Collaboration Author
700 1 _ |a Faber, Jennifer
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700 1 _ |a van de Warrenburg, Bart P C
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700 1 _ |a Schutter, Dennis J L G
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773 _ _ |a 10.1016/j.clinph.2025.2111405
|g Vol. 181, p. 2111405 -
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856 4 _ |y OpenAccess
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