%0 Journal Article
%A Noordam, Raymond
%A Wang, Wenyi
%A Nagarajan, Pavithra
%A Wang, Heming
%A Brown, Michael R
%A Bentley, Amy R
%A Hui, Qin
%A Kraja, Aldi T
%A Morrison, John L
%A O'Connel, Jeffrey R
%A Lee, Songmi
%A Schwander, Karen
%A Bartz, Traci M
%A de Las Fuentes, Lisa
%A Feitosa, Mary F
%A Guo, Xiuqing
%A Hanfei, Xu
%A Harris, Sarah E
%A Huang, Zhijie
%A Kals, Mart
%A Lefevre, Christophe
%A Mangino, Massimo
%A Milaneschi, Yuri
%A van der Most, Peter J
%A Pacheco, Natasha L
%A Palmer, Nicholette D
%A Rao, Varun
%A Rauramaa, Rainer
%A Sun, Quan
%A Tabara, Yasuharu
%A Vojinovic, Dina
%A Wang, Yujie
%A Weiss, Stefan
%A Yang, Qian
%A Zhao, Wei
%A Zhu, Wanying
%A Ansari, Md Abu Yusuf
%A Aschard, Hugues
%A Anugu, Pramod
%A Assimes, Themistocles L
%A Attia, John
%A Baker, Laura D
%A Ballantyne, Christie
%A Bazzano, Lydia
%A Boerwinkle, Eric
%A Cade, Brain
%A Chen, Hung-Hsin
%A Chen, Wei
%A Ida Chen, Yii-Der
%A Chen, Zekai
%A Cho, Kelly
%A De Anda-Duran, Ileana
%A Dimitrov, Latchezar
%A Do, Anh
%A Edwards, Todd
%A Faquih, Tariq
%A Hingorani, Aroon
%A Fisher-Hoch, Susan P
%A Gaziano, J Michael
%A Gharib, Sina A
%A Giri, Ayush
%A Ghanbari, Mohsen
%A Grabe, Hans Jörgen
%A Graff, Mariaelisa
%A Charles Gu, C.
%A He, Jiang
%A Heikkinen, Sami
%A Hixson, James
%A Ho, Yuk-Lam
%A Hood, Michelle M
%A Houghton, Serena C
%A Karvonen-Gutierrez, Carrie A
%A Kawaguchi, Takahisa
%A Kilpeläinen, Tuomas O
%A Komulainen, Pirjo
%A Lin, Henry J
%A Linchangco, Gregorio V
%A Luik, Annemarie I
%A Ma, Jintao
%A Meigs, James B
%A McCormick, Joseph B
%A Menni, Cristina
%A Nolte, Ilja M
%A Norris, Jill M
%A Petty, Lauren E
%A Polikowsky, Hannah G
%A Raffield, Laura M
%A Rich, Stephen S
%A Riha, Renata L
%A Russ, Thomas C
%A Ruiz-Narvaez, Edward A
%A Sitlani, Colleen M
%A Smith, Jennifer A
%A Snieder, Harold
%A Sofer, Tamar
%A Shen, Botong
%A Tang, Jingxian
%A Taylor, Kent D
%A Teder-Laving, Maris
%A Triatin, Rima
%A Tsai, Michael Y
%A Völzke, Henry
%A Westerman, Kenneth E
%A Xia, Rui
%A Yao, Jie
%A Young, Kristin L
%A Zhang, Ruiyuan
%A Zonderman, Alan B
%A Zhu, Xiaofeng
%A Below, Jennifer E
%A Cox, Simon R
%A Evans, Michelle
%A Fornage, Myriam
%A Fox, Ervin R
%A Franceschini, Nora
%A Harlow, Sioban D
%A Holliday, Elizabeth
%A Ikram, M Arfan
%A Kelly, Tanika
%A Lakka, Timo A
%A Lawlor, Deborah A
%A Li, Changwei
%A Liu, Ching-Ti
%A Mägi, Reedik
%A Manning, Alisa K
%A Matsuda, Fumihiko
%A Morrison, Alanna C
%A Nauck, Matthias
%A North, Kari E
%A Penninx, Brenda Wjh
%A Province, Michael A
%A Psaty, Bruce M
%A Rotter, Jerome I
%A Spector, Tim D
%A Wagenknecht, Lynne E
%A van Dijk, Ko Willems
%A Jaquish, Cashell E
%A Wilson, Peter Wf
%A Peyser, Patricia A
%A Munroe, Patricia B
%A de Vries, Paul S
%A Gauderman, W James
%A Sun, Yan V
%A Chen, Han
%A Miller, Clint L
%A Winkler, Thomas W
%A Rao, Dabeeru C
%A Redline, Susan
%A van Heemst, Diana
%T Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants.
%J Atherosclerosis
%V 412
%@ 0021-9150
%C Amsterdam [u.a.]
%I Elsevier Science
%M DZNE-2025-01371
%P 120603
%D 2026
%X Deviations from the population mean in sleep duration have been associated with increased risk for developing dyslipidemia and atherosclerotic cardiovascular disease, but the mechanism of effect is poorly characterized. We performed large-scale genome-wide gene-sleep interaction analyses of lipid levels to identify genetic variants underpinning the biomolecular pathways of sleep-associated lipid disturbances and to suggest possible druggable targets.We collected data from 55 cohorts with a combined sample size of 732,564 participants (87 
%K Humans
%K Genome-Wide Association Study
%K Male
%K Female
%K Sleep: genetics
%K Polymorphism, Single Nucleotide
%K Middle Aged
%K Dyslipidemias: genetics
%K Dyslipidemias: blood
%K Dyslipidemias: diagnosis
%K Genetic Predisposition to Disease
%K Triglycerides: blood
%K Lipids: blood
%K Adult
%K Aged
%K Genetic Loci
%K Phenotype
%K Cholesterol, LDL: blood
%K Cholesterol, HDL: blood
%K Biomarkers: blood
%K Sleep Wake Disorders: genetics
%K Sleep Wake Disorders: blood
%K Sleep Wake Disorders: physiopathology
%K Triglycerides (NLM Chemicals)
%K Lipids (NLM Chemicals)
%K Cholesterol, LDL (NLM Chemicals)
%K Cholesterol, HDL (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41325697
%R 10.1016/j.atherosclerosis.2025.120603
%U https://pub.dzne.de/record/282910