000282910 001__ 282910
000282910 005__ 20251217171018.0
000282910 0247_ $$2doi$$a10.1016/j.atherosclerosis.2025.120603
000282910 0247_ $$2pmid$$apmid:41325697
000282910 0247_ $$2ISSN$$a0021-9150
000282910 0247_ $$2ISSN$$a1567-5688
000282910 0247_ $$2ISSN$$a1878-5050
000282910 0247_ $$2ISSN$$a1879-1484
000282910 037__ $$aDZNE-2025-01371
000282910 041__ $$aEnglish
000282910 082__ $$a610
000282910 1001_ $$aNoordam, Raymond$$b0
000282910 245__ $$aGenome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants.
000282910 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2026
000282910 3367_ $$2DRIVER$$aarticle
000282910 3367_ $$2DataCite$$aOutput Types/Journal article
000282910 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1765963519_5351
000282910 3367_ $$2BibTeX$$aARTICLE
000282910 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000282910 3367_ $$00$$2EndNote$$aJournal Article
000282910 520__ $$aDeviations from the population mean in sleep duration have been associated with increased risk for developing dyslipidemia and atherosclerotic cardiovascular disease, but the mechanism of effect is poorly characterized. We performed large-scale genome-wide gene-sleep interaction analyses of lipid levels to identify genetic variants underpinning the biomolecular pathways of sleep-associated lipid disturbances and to suggest possible druggable targets.We collected data from 55 cohorts with a combined sample size of 732,564 participants (87 % European ancestry) with data on lipid traits (high-density lipoprotein [HDL-c] and low-density lipoprotein [LDL-c] cholesterol and triglycerides [TG]). Short (STST) and long (LTST) total sleep time were defined by the extreme 20 % of the age- and sex-standardized values within each cohort. Based on cohort-level summary statistics data, we performed meta-analyses for one-degree of freedom tests of interaction and two-degree of freedom joint tests of the SNP-main and -interaction effect on lipid levels.The one-degree of freedom variant-sleep interaction test identified 10 novel loci (Pint<5.0e-9), and we additionally identify 7 loci within the two-degree of freedom analyses (Pjoint<5.0e-9 in combination with Pint<6.6e-6). Multiple loci, including those mapped to APSH (target for aspartic and succinic acid) and SLC8A1 showed biological plausibility and druggability potential based on literature.Collectively, the 17 (9 with short and 8 with long sleep) loci provided evidence into the biomolecular mechanisms underlying sleep-associated lipid changes, including potential involvement of the vitamin D receptor pathway. Collectively, these findings may contribute developing novel interventions for treating dyslipidemia in people with sleep disturbances.
000282910 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000282910 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000282910 650_7 $$2NLM Chemicals$$aTriglycerides
000282910 650_7 $$2NLM Chemicals$$aLipids
000282910 650_7 $$2NLM Chemicals$$aCholesterol, LDL
000282910 650_7 $$2NLM Chemicals$$aCholesterol, HDL
000282910 650_7 $$2NLM Chemicals$$aBiomarkers
000282910 650_2 $$2MeSH$$aHumans
000282910 650_2 $$2MeSH$$aGenome-Wide Association Study
000282910 650_2 $$2MeSH$$aMale
000282910 650_2 $$2MeSH$$aFemale
000282910 650_2 $$2MeSH$$aSleep: genetics
000282910 650_2 $$2MeSH$$aPolymorphism, Single Nucleotide
000282910 650_2 $$2MeSH$$aMiddle Aged
000282910 650_2 $$2MeSH$$aDyslipidemias: genetics
000282910 650_2 $$2MeSH$$aDyslipidemias: blood
000282910 650_2 $$2MeSH$$aDyslipidemias: diagnosis
000282910 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000282910 650_2 $$2MeSH$$aTriglycerides: blood
000282910 650_2 $$2MeSH$$aLipids: blood
000282910 650_2 $$2MeSH$$aAdult
000282910 650_2 $$2MeSH$$aAged
000282910 650_2 $$2MeSH$$aGenetic Loci
000282910 650_2 $$2MeSH$$aPhenotype
000282910 650_2 $$2MeSH$$aCholesterol, LDL: blood
000282910 650_2 $$2MeSH$$aCholesterol, HDL: blood
000282910 650_2 $$2MeSH$$aBiomarkers: blood
000282910 650_2 $$2MeSH$$aSleep Wake Disorders: genetics
000282910 650_2 $$2MeSH$$aSleep Wake Disorders: blood
000282910 650_2 $$2MeSH$$aSleep Wake Disorders: physiopathology
000282910 7001_ $$aWang, Wenyi$$b1
000282910 7001_ $$aNagarajan, Pavithra$$b2
000282910 7001_ $$aWang, Heming$$b3
000282910 7001_ $$aBrown, Michael R$$b4
000282910 7001_ $$aBentley, Amy R$$b5
000282910 7001_ $$aHui, Qin$$b6
000282910 7001_ $$aKraja, Aldi T$$b7
000282910 7001_ $$aMorrison, John L$$b8
000282910 7001_ $$aO'Connel, Jeffrey R$$b9
000282910 7001_ $$aLee, Songmi$$b10
000282910 7001_ $$aSchwander, Karen$$b11
000282910 7001_ $$aBartz, Traci M$$b12
000282910 7001_ $$ade Las Fuentes, Lisa$$b13
000282910 7001_ $$aFeitosa, Mary F$$b14
000282910 7001_ $$aGuo, Xiuqing$$b15
000282910 7001_ $$aHanfei, Xu$$b16
000282910 7001_ $$aHarris, Sarah E$$b17
000282910 7001_ $$aHuang, Zhijie$$b18
000282910 7001_ $$aKals, Mart$$b19
000282910 7001_ $$aLefevre, Christophe$$b20
000282910 7001_ $$aMangino, Massimo$$b21
000282910 7001_ $$aMilaneschi, Yuri$$b22
000282910 7001_ $$avan der Most, Peter J$$b23
000282910 7001_ $$aPacheco, Natasha L$$b24
000282910 7001_ $$aPalmer, Nicholette D$$b25
000282910 7001_ $$aRao, Varun$$b26
000282910 7001_ $$aRauramaa, Rainer$$b27
000282910 7001_ $$aSun, Quan$$b28
000282910 7001_ $$aTabara, Yasuharu$$b29
000282910 7001_ $$aVojinovic, Dina$$b30
000282910 7001_ $$aWang, Yujie$$b31
000282910 7001_ $$aWeiss, Stefan$$b32
000282910 7001_ $$aYang, Qian$$b33
000282910 7001_ $$aZhao, Wei$$b34
000282910 7001_ $$aZhu, Wanying$$b35
000282910 7001_ $$aAnsari, Md Abu Yusuf$$b36
000282910 7001_ $$aAschard, Hugues$$b37
000282910 7001_ $$aAnugu, Pramod$$b38
000282910 7001_ $$aAssimes, Themistocles L$$b39
000282910 7001_ $$aAttia, John$$b40
000282910 7001_ $$aBaker, Laura D$$b41
000282910 7001_ $$aBallantyne, Christie$$b42
000282910 7001_ $$aBazzano, Lydia$$b43
000282910 7001_ $$aBoerwinkle, Eric$$b44
000282910 7001_ $$aCade, Brain$$b45
000282910 7001_ $$aChen, Hung-Hsin$$b46
000282910 7001_ $$0P:(DE-HGF)0$$aChen, Wei$$b47
000282910 7001_ $$aIda Chen, Yii-Der$$b48
000282910 7001_ $$aChen, Zekai$$b49
000282910 7001_ $$aCho, Kelly$$b50
000282910 7001_ $$aDe Anda-Duran, Ileana$$b51
000282910 7001_ $$aDimitrov, Latchezar$$b52
000282910 7001_ $$aDo, Anh$$b53
000282910 7001_ $$aEdwards, Todd$$b54
000282910 7001_ $$aFaquih, Tariq$$b55
000282910 7001_ $$aHingorani, Aroon$$b56
000282910 7001_ $$aFisher-Hoch, Susan P$$b57
000282910 7001_ $$aGaziano, J Michael$$b58
000282910 7001_ $$aGharib, Sina A$$b59
000282910 7001_ $$aGiri, Ayush$$b60
000282910 7001_ $$aGhanbari, Mohsen$$b61
000282910 7001_ $$0P:(DE-2719)2811781$$aGrabe, Hans Jörgen$$b62$$udzne
000282910 7001_ $$aGraff, Mariaelisa$$b63
000282910 7001_ $$aCharles Gu, C.$$b64
000282910 7001_ $$aHe, Jiang$$b65
000282910 7001_ $$aHeikkinen, Sami$$b66
000282910 7001_ $$aHixson, James$$b67
000282910 7001_ $$aHo, Yuk-Lam$$b68
000282910 7001_ $$aHood, Michelle M$$b69
000282910 7001_ $$aHoughton, Serena C$$b70
000282910 7001_ $$aKarvonen-Gutierrez, Carrie A$$b71
000282910 7001_ $$aKawaguchi, Takahisa$$b72
000282910 7001_ $$aKilpeläinen, Tuomas O$$b73
000282910 7001_ $$aKomulainen, Pirjo$$b74
000282910 7001_ $$aLin, Henry J$$b75
000282910 7001_ $$aLinchangco, Gregorio V$$b76
000282910 7001_ $$aLuik, Annemarie I$$b77
000282910 7001_ $$aMa, Jintao$$b78
000282910 7001_ $$aMeigs, James B$$b79
000282910 7001_ $$aMcCormick, Joseph B$$b80
000282910 7001_ $$aMenni, Cristina$$b81
000282910 7001_ $$aNolte, Ilja M$$b82
000282910 7001_ $$aNorris, Jill M$$b83
000282910 7001_ $$aPetty, Lauren E$$b84
000282910 7001_ $$aPolikowsky, Hannah G$$b85
000282910 7001_ $$aRaffield, Laura M$$b86
000282910 7001_ $$aRich, Stephen S$$b87
000282910 7001_ $$aRiha, Renata L$$b88
000282910 7001_ $$aRuss, Thomas C$$b89
000282910 7001_ $$aRuiz-Narvaez, Edward A$$b90
000282910 7001_ $$aSitlani, Colleen M$$b91
000282910 7001_ $$aSmith, Jennifer A$$b92
000282910 7001_ $$aSnieder, Harold$$b93
000282910 7001_ $$aSofer, Tamar$$b94
000282910 7001_ $$aShen, Botong$$b95
000282910 7001_ $$aTang, Jingxian$$b96
000282910 7001_ $$aTaylor, Kent D$$b97
000282910 7001_ $$aTeder-Laving, Maris$$b98
000282910 7001_ $$aTriatin, Rima$$b99
000282910 7001_ $$aTsai, Michael Y$$b100
000282910 7001_ $$aVölzke, Henry$$b101
000282910 7001_ $$aWesterman, Kenneth E$$b102
000282910 7001_ $$aXia, Rui$$b103
000282910 7001_ $$aYao, Jie$$b104
000282910 7001_ $$aYoung, Kristin L$$b105
000282910 7001_ $$aZhang, Ruiyuan$$b106
000282910 7001_ $$aZonderman, Alan B$$b107
000282910 7001_ $$aZhu, Xiaofeng$$b108
000282910 7001_ $$aBelow, Jennifer E$$b109
000282910 7001_ $$aCox, Simon R$$b110
000282910 7001_ $$aEvans, Michelle$$b111
000282910 7001_ $$aFornage, Myriam$$b112
000282910 7001_ $$aFox, Ervin R$$b113
000282910 7001_ $$aFranceschini, Nora$$b114
000282910 7001_ $$aHarlow, Sioban D$$b115
000282910 7001_ $$aHolliday, Elizabeth$$b116
000282910 7001_ $$aIkram, M Arfan$$b117
000282910 7001_ $$aKelly, Tanika$$b118
000282910 7001_ $$aLakka, Timo A$$b119
000282910 7001_ $$aLawlor, Deborah A$$b120
000282910 7001_ $$aLi, Changwei$$b121
000282910 7001_ $$aLiu, Ching-Ti$$b122
000282910 7001_ $$aMägi, Reedik$$b123
000282910 7001_ $$aManning, Alisa K$$b124
000282910 7001_ $$aMatsuda, Fumihiko$$b125
000282910 7001_ $$aMorrison, Alanna C$$b126
000282910 7001_ $$aNauck, Matthias$$b127
000282910 7001_ $$aNorth, Kari E$$b128
000282910 7001_ $$aPenninx, Brenda Wjh$$b129
000282910 7001_ $$aProvince, Michael A$$b130
000282910 7001_ $$aPsaty, Bruce M$$b131
000282910 7001_ $$aRotter, Jerome I$$b132
000282910 7001_ $$aSpector, Tim D$$b133
000282910 7001_ $$aWagenknecht, Lynne E$$b134
000282910 7001_ $$avan Dijk, Ko Willems$$b135
000282910 7001_ $$aStudy, Lifelines Cohort$$b136$$eCollaboration Author
000282910 7001_ $$aProgram, Million Veteran$$b137$$eCollaboration Author
000282910 7001_ $$aJaquish, Cashell E$$b138
000282910 7001_ $$aWilson, Peter Wf$$b139
000282910 7001_ $$aPeyser, Patricia A$$b140
000282910 7001_ $$aMunroe, Patricia B$$b141
000282910 7001_ $$ade Vries, Paul S$$b142
000282910 7001_ $$aGauderman, W James$$b143
000282910 7001_ $$aSun, Yan V$$b144
000282910 7001_ $$aChen, Han$$b145
000282910 7001_ $$aMiller, Clint L$$b146
000282910 7001_ $$aWinkler, Thomas W$$b147
000282910 7001_ $$aRao, Dabeeru C$$b148
000282910 7001_ $$aRedline, Susan$$b149
000282910 7001_ $$avan Heemst, Diana$$b150
000282910 773__ $$0PERI:(DE-600)1499887-7$$a10.1016/j.atherosclerosis.2025.120603$$gVol. 412, p. 120603 -$$p120603$$tAtherosclerosis$$v412$$x0021-9150$$y2026
000282910 8564_ $$uhttps://pub.dzne.de/record/282910/files/DZNE-2025-01371.pdf$$yOpenAccess
000282910 8564_ $$uhttps://pub.dzne.de/record/282910/files/DZNE-2025-01371.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000282910 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811781$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b62$$kDZNE
000282910 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000282910 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-06
000282910 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-06
000282910 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-06
000282910 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-06
000282910 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2024-12-06
000282910 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bATHEROSCLEROSIS : 2022$$d2024-12-06
000282910 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2024-12-06
000282910 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-06
000282910 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-06
000282910 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000282910 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000282910 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2024-12-06
000282910 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bATHEROSCLEROSIS : 2022$$d2024-12-06
000282910 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-06
000282910 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2024-12-06
000282910 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2024-12-06$$wger
000282910 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-06
000282910 9201_ $$0I:(DE-2719)5000001$$kAG Grabe$$lBiomarkers of Dementia in the General Population$$x0
000282910 980__ $$ajournal
000282910 980__ $$aVDB
000282910 980__ $$aUNRESTRICTED
000282910 980__ $$aI:(DE-2719)5000001
000282910 9801_ $$aFullTexts