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@ARTICLE{Noordam:282910,
      author       = {Noordam, Raymond and Wang, Wenyi and Nagarajan, Pavithra
                      and Wang, Heming and Brown, Michael R and Bentley, Amy R and
                      Hui, Qin and Kraja, Aldi T and Morrison, John L and
                      O'Connel, Jeffrey R and Lee, Songmi and Schwander, Karen and
                      Bartz, Traci M and de Las Fuentes, Lisa and Feitosa, Mary F
                      and Guo, Xiuqing and Hanfei, Xu and Harris, Sarah E and
                      Huang, Zhijie and Kals, Mart and Lefevre, Christophe and
                      Mangino, Massimo and Milaneschi, Yuri and van der Most,
                      Peter J and Pacheco, Natasha L and Palmer, Nicholette D and
                      Rao, Varun and Rauramaa, Rainer and Sun, Quan and Tabara,
                      Yasuharu and Vojinovic, Dina and Wang, Yujie and Weiss,
                      Stefan and Yang, Qian and Zhao, Wei and Zhu, Wanying and
                      Ansari, Md Abu Yusuf and Aschard, Hugues and Anugu, Pramod
                      and Assimes, Themistocles L and Attia, John and Baker, Laura
                      D and Ballantyne, Christie and Bazzano, Lydia and
                      Boerwinkle, Eric and Cade, Brain and Chen, Hung-Hsin and
                      Chen, Wei and Ida Chen, Yii-Der and Chen, Zekai and Cho,
                      Kelly and De Anda-Duran, Ileana and Dimitrov, Latchezar and
                      Do, Anh and Edwards, Todd and Faquih, Tariq and Hingorani,
                      Aroon and Fisher-Hoch, Susan P and Gaziano, J Michael and
                      Gharib, Sina A and Giri, Ayush and Ghanbari, Mohsen and
                      Grabe, Hans Jörgen and Graff, Mariaelisa and Charles Gu, C.
                      and He, Jiang and Heikkinen, Sami and Hixson, James and Ho,
                      Yuk-Lam and Hood, Michelle M and Houghton, Serena C and
                      Karvonen-Gutierrez, Carrie A and Kawaguchi, Takahisa and
                      Kilpeläinen, Tuomas O and Komulainen, Pirjo and Lin, Henry
                      J and Linchangco, Gregorio V and Luik, Annemarie I and Ma,
                      Jintao and Meigs, James B and McCormick, Joseph B and Menni,
                      Cristina and Nolte, Ilja M and Norris, Jill M and Petty,
                      Lauren E and Polikowsky, Hannah G and Raffield, Laura M and
                      Rich, Stephen S and Riha, Renata L and Russ, Thomas C and
                      Ruiz-Narvaez, Edward A and Sitlani, Colleen M and Smith,
                      Jennifer A and Snieder, Harold and Sofer, Tamar and Shen,
                      Botong and Tang, Jingxian and Taylor, Kent D and
                      Teder-Laving, Maris and Triatin, Rima and Tsai, Michael Y
                      and Völzke, Henry and Westerman, Kenneth E and Xia, Rui and
                      Yao, Jie and Young, Kristin L and Zhang, Ruiyuan and
                      Zonderman, Alan B and Zhu, Xiaofeng and Below, Jennifer E
                      and Cox, Simon R and Evans, Michelle and Fornage, Myriam and
                      Fox, Ervin R and Franceschini, Nora and Harlow, Sioban D and
                      Holliday, Elizabeth and Ikram, M Arfan and Kelly, Tanika and
                      Lakka, Timo A and Lawlor, Deborah A and Li, Changwei and
                      Liu, Ching-Ti and Mägi, Reedik and Manning, Alisa K and
                      Matsuda, Fumihiko and Morrison, Alanna C and Nauck, Matthias
                      and North, Kari E and Penninx, Brenda Wjh and Province,
                      Michael A and Psaty, Bruce M and Rotter, Jerome I and
                      Spector, Tim D and Wagenknecht, Lynne E and van Dijk, Ko
                      Willems and Jaquish, Cashell E and Wilson, Peter Wf and
                      Peyser, Patricia A and Munroe, Patricia B and de Vries, Paul
                      S and Gauderman, W James and Sun, Yan V and Chen, Han and
                      Miller, Clint L and Winkler, Thomas W and Rao, Dabeeru C and
                      Redline, Susan and van Heemst, Diana},
      collaboration = {Study, Lifelines Cohort and Program, Million Veteran},
      title        = {{G}enome-wide gene-sleep interaction study identifies novel
                      lipid loci in 732,564 participants.},
      journal      = {Atherosclerosis},
      volume       = {412},
      issn         = {0021-9150},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2025-01371},
      pages        = {120603},
      year         = {2026},
      abstract     = {Deviations from the population mean in sleep duration have
                      been associated with increased risk for developing
                      dyslipidemia and atherosclerotic cardiovascular disease, but
                      the mechanism of effect is poorly characterized. We
                      performed large-scale genome-wide gene-sleep interaction
                      analyses of lipid levels to identify genetic variants
                      underpinning the biomolecular pathways of sleep-associated
                      lipid disturbances and to suggest possible druggable
                      targets.We collected data from 55 cohorts with a combined
                      sample size of 732,564 participants (87 $\%$ European
                      ancestry) with data on lipid traits (high-density
                      lipoprotein [HDL-c] and low-density lipoprotein [LDL-c]
                      cholesterol and triglycerides [TG]). Short (STST) and long
                      (LTST) total sleep time were defined by the extreme 20 $\%$
                      of the age- and sex-standardized values within each cohort.
                      Based on cohort-level summary statistics data, we performed
                      meta-analyses for one-degree of freedom tests of interaction
                      and two-degree of freedom joint tests of the SNP-main and
                      -interaction effect on lipid levels.The one-degree of
                      freedom variant-sleep interaction test identified 10 novel
                      loci (Pint<5.0e-9), and we additionally identify 7 loci
                      within the two-degree of freedom analyses (Pjoint<5.0e-9 in
                      combination with Pint<6.6e-6). Multiple loci, including
                      those mapped to APSH (target for aspartic and succinic acid)
                      and SLC8A1 showed biological plausibility and druggability
                      potential based on literature.Collectively, the 17 (9 with
                      short and 8 with long sleep) loci provided evidence into the
                      biomolecular mechanisms underlying sleep-associated lipid
                      changes, including potential involvement of the vitamin D
                      receptor pathway. Collectively, these findings may
                      contribute developing novel interventions for treating
                      dyslipidemia in people with sleep disturbances.},
      keywords     = {Humans / Genome-Wide Association Study / Male / Female /
                      Sleep: genetics / Polymorphism, Single Nucleotide / Middle
                      Aged / Dyslipidemias: genetics / Dyslipidemias: blood /
                      Dyslipidemias: diagnosis / Genetic Predisposition to Disease
                      / Triglycerides: blood / Lipids: blood / Adult / Aged /
                      Genetic Loci / Phenotype / Cholesterol, LDL: blood /
                      Cholesterol, HDL: blood / Biomarkers: blood / Sleep Wake
                      Disorders: genetics / Sleep Wake Disorders: blood / Sleep
                      Wake Disorders: physiopathology / Triglycerides (NLM
                      Chemicals) / Lipids (NLM Chemicals) / Cholesterol, LDL (NLM
                      Chemicals) / Cholesterol, HDL (NLM Chemicals) / Biomarkers
                      (NLM Chemicals)},
      cin          = {AG Grabe},
      ddc          = {610},
      cid          = {I:(DE-2719)5000001},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41325697},
      doi          = {10.1016/j.atherosclerosis.2025.120603},
      url          = {https://pub.dzne.de/record/282910},
}