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000282913 1001_ $$0P:(DE-2719)9001524$$aBopp, Verena$$b0
000282913 245__ $$aTargeting Cdc42 improves motor phenotype in Parkinson’s disease mice and reveals age-dependent susceptibility to α-synuclein
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000282913 520__ $$aAging and accumulation of α-synuclein (α-syn) oligomers in the brain are indisputably linked to Parkinson’s disease (PD). Using an inducible α-syn oligomer mouse model, we demonstrate that the induction of PD-associated α-syn oligomers for the same time span caused PD-associated symptoms only in aged, but not in young mice. Biochemical studies revealed that α-syn oligomer formation precedes motor decline, with age and α-syn expression jointly determining the motor phenotype. Single-nucleus RNA sequencing (snRNA-seq) identified a PD-related transcriptional signature in basal ganglia neurons (BGNs), which overlapped in part with aging-associated changes. Short-term pharmacological inhibition of the small RhoGTPase CDC42 in aged, symptomatic animals improved motor function without reducing oligomer levels. These findings indicate that aging processes strongly influence the susceptibility to PD-like symptoms and that targeting age-related pathways, rather than α-syn oligomer burden alone, may provide effective strategies to improve outcomes in PD.
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000282913 7001_ $$0P:(DE-2719)9002103$$aLee, Jaehyun$$b1$$eFirst author
000282913 7001_ $$0P:(DE-2719)9001560$$aOeckl, Patrick$$b2
000282913 7001_ $$0P:(DE-2719)9001523$$aKühlwein, Julia$$b3
000282913 7001_ $$0P:(DE-2719)9001519$$aGrozdanov, Veselin$$b4
000282913 7001_ $$aKiechle, Martin$$b5
000282913 7001_ $$aMayer, Benjamin$$b6
000282913 7001_ $$aMöhrle, Bettina$$b7
000282913 7001_ $$aGeiger, Hartmut$$b8
000282913 7001_ $$0P:(DE-2719)9001513$$aDanzer, Karin M.$$b9$$eLast author
000282913 773__ $$0PERI:(DE-600)2927064-9$$a10.1016/j.isci.2025.114217$$gVol. 28, no. 12, p. 114217 -$$n12$$p114217$$tiScience$$v28$$x2589-0042$$y2025
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