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@MISC{Mller:282929,
      author       = {Müller, Stephan A and Lichtenthaler, Stefan},
      title        = {{D}ataset: {A} proteomics resource for human i{PSC}-derived
                      endothelial cells (i{EC}), smooth muscle cells (i{SMC}),
                      pericytes (i{PC}) and astrocytes (i{AS}) in comparison to
                      human primary cells - technical and biological replicates
                      ({P}roject {PXD}066414)},
      publisher    = {PRoteomics IDEntifications Database},
      reportid     = {DZNE-2025-01390},
      year         = {2025},
      abstract     = {Integrity of the blood-brain barrier (BBB) is critical for
                      brain homeostasis, and its malfunction contributes to
                      neurovascular and neurodegenerative disorders. So far,
                      mechanistic studies on BBB function have been mostly
                      conducted in rodent and non-physiological in vitro models,
                      which recapitulate some disease features, but have limited
                      translatability to humans and pose challenges for drug
                      discovery. Here we report on a fully human iPSC-derived,
                      microfluidic 3D BBB model consisting of endothelial cells
                      (EC), mural cells, and astrocytes. Our model expresses
                      typical cell fate markers, forms a barrier in vessel-like
                      tubes, and enables perfusion, including with human blood. We
                      optimized iPSC differentiations and validated cellular fates
                      by comparison to published datasets and extensive
                      benchmarking vs. primary cells with proteomic profiles
                      provided in an online database
                      (https://dbNeuroVasP.isd-muc.de).},
      cin          = {AG Lichtenthaler},
      cid          = {I:(DE-2719)1110006},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)32},
      url          = {https://pub.dzne.de/record/282929},
}