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@MISC{Mller:282930,
      author       = {Müller, Stephan A and Lichtenthaler, Stefan},
      title        = {{D}ataset: {A} proteomics resource for human i{PSC}-derived
                      endothelial cells (i{EC}), smooth muscle cells (i{SMC}),
                      pericytes (i{PC}) and astrocytes (i{AS}) in comparison to
                      i{PSC}s and human primary cells - technical replicates
                      ({P}roject {PXD}051959)},
      publisher    = {PRoteomics IDEntifications Database},
      reportid     = {DZNE-2025-01391},
      year         = {2025},
      abstract     = {Function and integrity of the blood-brain-barrier (BBB) is
                      crucial for brain homeostasis, and its malfunction
                      critically contributes to neurovascular and
                      neurodegenerative disorders, including cerebral small vessel
                      disease (SVD), a common cause of stroke and vascular
                      dementia. So far, mechanistic studies on BBB function have
                      been mostly conducted in mice and non-physiological in vitro
                      models, which recapitulate disease features, but often lack
                      complex phenotypes, have limited translatability to humans,
                      and pose challenges for drug discovery. Therefore, we aimed
                      to establish a fully iPSC-derived 3D model of the human
                      blood-brain-barrier. To characterize and validate our
                      somatic cell differentiation protocols we compared our
                      iPSC-derived cells with commercially available human primary
                      cells: brain microvascular endothelial cells (pEC), human
                      umbilical vein endothelial cells (HUVEC), brain vascular
                      pericytes (pPC), brain vascular smooth muscle cells (pSMC)
                      and midbrain astrocytes (pAS).},
      cin          = {AG Lichtenthaler},
      cid          = {I:(DE-2719)1110006},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)32},
      url          = {https://pub.dzne.de/record/282930},
}