%0 Chart or Table
%A Müller, Stephan A
%A Lichtenthaler, Stefan
%T Dataset: CSF and brain proteomics of Trem2-mKate2 KI/wt.APPSAA/SAA.hTfR KI/KI mice (Project PXD065438)
%I PRoteomics IDEntifications Database
%M DZNE-2025-01396
%D 2025
%X Triggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglial activity and loss-of-function coding variants are major risk factors for late onset Alzheimer’s disease (LOAD). To better understand the molecular and functional changes associated with TREM2 signalling in microglia, we generated a TREM2 reporter mouse model. Experimental mice expressed the reporter heterozygous while AppSAA and the hTfR knock-in were homozygous (Trem2-mKate2 KI/wt.APPSAA/SAA.hTfR KI/KI) and were treated with the antibody transport vehicle coupled TREM2 agonist antibody ATV:4D9. After the treatment CSF and brain samples were colleceted for proteomics analyses.
%F PUB:(DE-HGF)32
%9 Dataset
%U https://pub.dzne.de/record/282935