000282935 001__ 282935
000282935 005__ 20251218141650.0
000282935 037__ $$aDZNE-2025-01396
000282935 1001_ $$0P:(DE-2719)2810938$$aMüller, Stephan A$$b0$$udzne
000282935 245__ $$aDataset: CSF and brain proteomics of Trem2-mKate2 KI/wt.APPSAA/SAA.hTfR KI/KI mice (Project PXD065438)
000282935 260__ $$bPRoteomics IDEntifications Database$$c2025
000282935 3367_ $$2BibTeX$$aMISC
000282935 3367_ $$0PUB:(DE-HGF)32$$2PUB:(DE-HGF)$$aDataset$$bdataset$$mdataset$$s1766063788_31262
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000282935 3367_ $$2ORCID$$aDATA_SET
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000282935 520__ $$aTriggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglial activity and loss-of-function coding variants are major risk factors for late onset Alzheimer’s disease (LOAD). To better understand the molecular and functional changes associated with TREM2 signalling in microglia, we generated a TREM2 reporter mouse model. Experimental mice expressed the reporter heterozygous while AppSAA and the hTfR knock-in were homozygous (Trem2-mKate2 KI/wt.APPSAA/SAA.hTfR KI/KI) and were treated with the antibody transport vehicle coupled TREM2 agonist antibody ATV:4D9. After the treatment CSF and brain samples were colleceted for proteomics analyses.
000282935 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
000282935 7001_ $$0P:(DE-2719)2181459$$aLichtenthaler, Stefan$$b1$$udzne
000282935 8564_ $$uhttps://wwwdev.ebi.ac.uk/pride/archive/projects/PXD065438
000282935 909CO $$ooai:pub.dzne.de:282935$$pVDB
000282935 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810938$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000282935 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2181459$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000282935 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x0
000282935 9141_ $$y2025
000282935 9201_ $$0I:(DE-2719)1110006$$kAG Lichtenthaler$$lNeuroproteomics$$x0
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000282935 980__ $$aI:(DE-2719)1110006
000282935 980__ $$aUNRESTRICTED