TY  - CHART
AU  - Müller, Stephan A
AU  - Lichtenthaler, Stefan
TI  - Dataset: CSF and brain proteomics of Trem2-mKate2 KI/wt.APPSAA/SAA.hTfR KI/KI mice (Project PXD065438)
PB  - PRoteomics IDEntifications Database
M1  - DZNE-2025-01396
PY  - 2025
AB  - Triggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglial activity and loss-of-function coding variants are major risk factors for late onset Alzheimer’s disease (LOAD). To better understand the molecular and functional changes associated with TREM2 signalling in microglia, we generated a TREM2 reporter mouse model. Experimental mice expressed the reporter heterozygous while AppSAA and the hTfR knock-in were homozygous (Trem2-mKate2 KI/wt.APPSAA/SAA.hTfR KI/KI) and were treated with the antibody transport vehicle coupled TREM2 agonist antibody ATV:4D9. After the treatment CSF and brain samples were colleceted for proteomics analyses.
LB  - PUB:(DE-HGF)32
UR  - https://pub.dzne.de/record/282935
ER  -