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@MISC{Mller:282935,
      author       = {Müller, Stephan A and Lichtenthaler, Stefan},
      title        = {{D}ataset: {CSF} and brain proteomics of {T}rem2-m{K}ate2
                      {KI}/wt.{APPSAA}/{SAA}.h{T}f{R} {KI}/{KI} mice ({P}roject
                      {PXD}065438)},
      publisher    = {PRoteomics IDEntifications Database},
      reportid     = {DZNE-2025-01396},
      year         = {2025},
      abstract     = {Triggering receptor expressed on myeloid cells 2 (TREM2) is
                      a central regulator of microglial activity and
                      loss-of-function coding variants are major risk factors for
                      late onset Alzheimer’s disease (LOAD). To better
                      understand the molecular and functional changes associated
                      with TREM2 signalling in microglia, we generated a TREM2
                      reporter mouse model. Experimental mice expressed the
                      reporter heterozygous while AppSAA and the hTfR knock-in
                      were homozygous (Trem2-mKate2 KI/wt.APPSAA/SAA.hTfR KI/KI)
                      and were treated with the antibody transport vehicle coupled
                      TREM2 agonist antibody ATV:4D9. After the treatment CSF and
                      brain samples were colleceted for proteomics analyses.},
      cin          = {AG Lichtenthaler},
      cid          = {I:(DE-2719)1110006},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)32},
      url          = {https://pub.dzne.de/record/282935},
}