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@MISC{Mller:282937,
      author       = {Müller, Stephan A and Lichtenthaler, Stefan},
      title        = {{D}ataset: {S}ecretome and lysate proteomics of primary
                      murine neurons with inactive {BACE}1 ({P}roject
                      {PXD}065011)},
      publisher    = {PRoteomics IDEntifications Database},
      reportid     = {DZNE-2025-01398},
      year         = {2025},
      abstract     = {The β-secretase BACE1 has become a prime target in
                      Alzheimer’s disease (AD) therapy, because it drives the
                      production of pathogenic amyloid β peptides. However,
                      clinical trials with BACE1-targeting drugs were halted due
                      to adverse effects on cognitive performance. We propose here
                      that cognitive impairment by BACE1 inhibitors may be a
                      corollary of a higher function of BACE1 related to proper
                      sleep regulation. To address non-enzymatic effects of BACE1
                      on ion channels likely involved in the sleep–wake cycle,
                      we analyzed sleep patterns in both BACE1-KO mice and a newly
                      generated transgenic line expressing a proteolysis-deficient
                      BACE1 variant (BACE1-KI). To investigate changes in the
                      cellular proteome as well as the secretome, primary neurons
                      were metabolically labeled with ManNAz and the secretome was
                      anlyzed using the hiSPECS method. The results showed
                      areduction of several BACE1 substrates in the secretome
                      (i.e. SEZ6, APLP1) as well as an accumulation of some BACE1
                      substrates in the lysate (i.e. APLP1, SEZ6, CNTN2).},
      cin          = {AG Lichtenthaler},
      cid          = {I:(DE-2719)1110006},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)32},
      url          = {https://pub.dzne.de/record/282937},
}