TY  - JOUR
AU  - Hähnel, Tom
AU  - More, Shammi
AU  - Hoffstaedter, Felix
AU  - Patil, Kaustubh R
AU  - Fröhlich, Holger
AU  - Falkenburger, Björn H
TI  - Brain age gap as predictor of disease progression in Parkinson's disease.
JO  - npj Parkinson's Disease
VL  - 11
IS  - 1
SN  - 2373-8057
CY  - [London]
PB  - Springer Nature
M1  - DZNE-2025-01420
SP  - 353
PY  - 2025
AB  - Parkinson's disease (PD) exhibits high heterogeneity in disease progression, complicating management and increasing required sample sizes for clinical trials. This study evaluates Brain Age Gap (BAG)-the difference between brain age and chronological age-for predicting disease progression in PD. Structural MRI-derived gray matter volumes were analyzed for 451 early-stage PD patients and 172 healthy controls from the PPMI cohort. PD patients had a baseline BAG of 1.1 years, with fast-progressing patients exhibiting a BAG of 3.0 years, whereas slow-progressing patients resembled the BAG of healthy controls. Higher BAG was associated with more severe baseline symptoms, faster cognitive decline in several domains, increased hazard of developing mild cognitive impairment, and faster progression of dopaminergic neuron loss in longitudinal DaTSCANs. BAG-based patient stratification could reduce sample sizes of randomized clinical trials by 23-58
LB  - PUB:(DE-HGF)16
C6  - pmid:41361244
C2  - pmc:PMC12689644
DO  - DOI:10.1038/s41531-025-01232-4
UR  - https://pub.dzne.de/record/282968
ER  -