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@ARTICLE{Hhnel:282968,
      author       = {Hähnel, Tom and More, Shammi and Hoffstaedter, Felix and
                      Patil, Kaustubh R and Fröhlich, Holger and Falkenburger,
                      Björn H},
      title        = {{B}rain age gap as predictor of disease progression in
                      {P}arkinson's disease.},
      journal      = {npj Parkinson's Disease},
      volume       = {11},
      number       = {1},
      issn         = {2373-8057},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-01420},
      pages        = {353},
      year         = {2025},
      abstract     = {Parkinson's disease (PD) exhibits high heterogeneity in
                      disease progression, complicating management and increasing
                      required sample sizes for clinical trials. This study
                      evaluates Brain Age Gap (BAG)-the difference between brain
                      age and chronological age-for predicting disease progression
                      in PD. Structural MRI-derived gray matter volumes were
                      analyzed for 451 early-stage PD patients and 172 healthy
                      controls from the PPMI cohort. PD patients had a baseline
                      BAG of 1.1 years, with fast-progressing patients exhibiting
                      a BAG of 3.0 years, whereas slow-progressing patients
                      resembled the BAG of healthy controls. Higher BAG was
                      associated with more severe baseline symptoms, faster
                      cognitive decline in several domains, increased hazard of
                      developing mild cognitive impairment, and faster progression
                      of dopaminergic neuron loss in longitudinal DaTSCANs.
                      BAG-based patient stratification could reduce sample sizes
                      of randomized clinical trials by $23-58\%.$ These findings
                      suggest BAG as a prognostic biomarker of disease
                      progression, which may accelerate the development of
                      disease-modifying treatments.},
      cin          = {AG Falkenburger},
      ddc          = {610},
      cid          = {I:(DE-2719)1710012},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41361244},
      pmc          = {pmc:PMC12689644},
      doi          = {10.1038/s41531-025-01232-4},
      url          = {https://pub.dzne.de/record/282968},
}