TY  - JOUR
AU  - Aziz, N. Ahmad
AU  - Claassen, Daniel
AU  - Petersén, Åsa
AU  - Weydt, Patrick
AU  - Network, European Huntington's Disease
AU  - Group, Huntington Study
TI  - β-Blocker effects in huntington's disease: A caution on clinical interpretation.
JO  - Journal of Huntington's disease
VL  - Advance online publication
SN  - 1879-6397
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2025-01422
SP  - -
PY  - 2025
AB  - A recent retrospective analysis of Enroll HD data suggesting β-blockers slow Huntington's disease progression has triggered patient demand but requires caution. The findings rely solely on small observational subsets and are vulnerable to bias and confounding. A prior Mendelian-randomization study found no causal link between β-blockers and HD onset; instead, genetically higher blood pressure was associated with later onset, raising concern that β-blockers' BP-lowering effects could be harmful. HD patients also have lower hypertension rates, and β-blockers carry risks such as depression and bradycardia. Given their heterogeneous mechanisms, rigorous experimental and clinical trials are needed before any clinical recommendations.
KW  - bioethics (Other)
KW  - biostatistics (Other)
KW  - clinical care (Other)
KW  - clinical trials (Other)
KW  - ethics (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41395805
DO  - DOI:10.1177/18796397251401745
UR  - https://pub.dzne.de/record/282970
ER  -