% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Aziz:282970,
      author       = {Aziz, N. Ahmad and Claassen, Daniel and Petersén, Åsa and
                      Weydt, Patrick and Network, European Huntington's Disease
                      and Group, Huntington Study},
      title        = {β-{B}locker effects in huntington's disease: {A} caution
                      on clinical interpretation.},
      journal      = {Journal of Huntington's disease},
      volume       = {Advance online publication},
      issn         = {1879-6397},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {DZNE-2025-01422},
      pages        = {-},
      year         = {2025},
      abstract     = {A recent retrospective analysis of Enroll HD data
                      suggesting β-blockers slow Huntington's disease progression
                      has triggered patient demand but requires caution. The
                      findings rely solely on small observational subsets and are
                      vulnerable to bias and confounding. A prior
                      Mendelian-randomization study found no causal link between
                      β-blockers and HD onset; instead, genetically higher blood
                      pressure was associated with later onset, raising concern
                      that β-blockers' BP-lowering effects could be harmful. HD
                      patients also have lower hypertension rates, and β-blockers
                      carry risks such as depression and bradycardia. Given their
                      heterogeneous mechanisms, rigorous experimental and clinical
                      trials are needed before any clinical recommendations.},
      keywords     = {bioethics (Other) / biostatistics (Other) / clinical care
                      (Other) / clinical trials (Other) / ethics (Other)},
      cin          = {Clinical Research (Bonn) / AG Aziz},
      ddc          = {610},
      cid          = {I:(DE-2719)1011001 / I:(DE-2719)5000071},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354) / 353
                      - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-354 / G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41395805},
      doi          = {10.1177/18796397251401745},
      url          = {https://pub.dzne.de/record/282970},
}