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| 001 | 282970 | ||
| 005 | 20251219154046.0 | ||
| 024 | 7 | _ | |a 10.1177/18796397251401745 |2 doi |
| 024 | 7 | _ | |a pmid:41395805 |2 pmid |
| 024 | 7 | _ | |a 1879-6397 |2 ISSN |
| 024 | 7 | _ | |a 1879-6400 |2 ISSN |
| 037 | _ | _ | |a DZNE-2025-01422 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Aziz, N. Ahmad |0 P:(DE-2719)2812578 |b 0 |e First author |
| 245 | _ | _ | |a β-Blocker effects in huntington's disease: A caution on clinical interpretation. |
| 260 | _ | _ | |a Amsterdam |c 2025 |b IOS Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1766155162_31937 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a A recent retrospective analysis of Enroll HD data suggesting β-blockers slow Huntington's disease progression has triggered patient demand but requires caution. The findings rely solely on small observational subsets and are vulnerable to bias and confounding. A prior Mendelian-randomization study found no causal link between β-blockers and HD onset; instead, genetically higher blood pressure was associated with later onset, raising concern that β-blockers' BP-lowering effects could be harmful. HD patients also have lower hypertension rates, and β-blockers carry risks such as depression and bradycardia. Given their heterogeneous mechanisms, rigorous experimental and clinical trials are needed before any clinical recommendations. |
| 536 | _ | _ | |a 354 - Disease Prevention and Healthy Aging (POF4-354) |0 G:(DE-HGF)POF4-354 |c POF4-354 |f POF IV |x 0 |
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| 650 | _ | 7 | |a bioethics |2 Other |
| 650 | _ | 7 | |a biostatistics |2 Other |
| 650 | _ | 7 | |a clinical care |2 Other |
| 650 | _ | 7 | |a clinical trials |2 Other |
| 650 | _ | 7 | |a ethics |2 Other |
| 700 | 1 | _ | |a Claassen, Daniel |0 0000-0002-9853-4902 |b 1 |
| 700 | 1 | _ | |a Petersén, Åsa |0 0000-0001-5488-1200 |b 2 |
| 700 | 1 | _ | |a Weydt, Patrick |0 P:(DE-2719)9001116 |b 3 |e Last author |
| 700 | 1 | _ | |a Network, European Huntington's Disease |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Group, Huntington Study |0 P:(DE-HGF)0 |b 5 |
| 773 | _ | _ | |a 10.1177/18796397251401745 |g p. 18796397251401745 |0 PERI:(DE-600)2673033-9 |p - |t Journal of Huntington's disease |v Advance online publication |y 2025 |x 1879-6397 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/282970/files/DZNE-2025-1422_Restricted.pdf |
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| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)2812578 |
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| 914 | 1 | _ | |y 2025 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b J HUNTINGTONS DIS : 2022 |d 2024-12-17 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2024-12-17 |
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| 920 | 1 | _ | |0 I:(DE-2719)1011001 |k Clinical Research (Bonn) |l Clinical Research Coordination |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)5000071 |k AG Aziz |l Population & Clinical Neuroepidemiology |x 1 |
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