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| Home > Documents in Process > Developing a novel reference region for [18F]PI-2620-PET imaging to facilitate the assessment of 4-repeat tauopathies. > print |
| 001 | 282975 | ||
| 005 | 20251219153354.0 | ||
| 024 | 7 | _ | |a 10.1007/s00259-025-07396-8 |2 doi |
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| 037 | _ | _ | |a DZNE-2025-01427 |
| 041 | _ | _ | |a English |
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| 100 | 1 | _ | |a Frontzkowski, Lukas |0 0000-0001-9321-956X |b 0 |
| 245 | _ | _ | |a Developing a novel reference region for [18F]PI-2620-PET imaging to facilitate the assessment of 4-repeat tauopathies. |
| 260 | _ | _ | |a Heidelberg [u.a.] |c 2025 |b Springer-Verl. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1766154775_31934 |2 PUB:(DE-HGF) |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Progressive supranuclear palsy (PSP) is a fatal 4-repeat (4R) tauopathy with progressive movement phenotypes. In-vivo 4R tau biomarkers are therefore crucial for PSP diagnosis, monitoring, and treatment evaluation. The tau-PET tracer [18F]PI-2620 binds to 4R tau and shows increased uptake in PSP-associated regions (e.g., globus pallidus), and is therefore a candidate 4R tau biomarker. However, commonly used cerebellar tau-PET reference regions show regional proximity to cerebellar 4R tau deposits in PSP, confounding semiquantitative [18F]PI-2620 assessments. Therefore, we employed bias-free image-derived input function (IDIF) PET quantification to identify an optimized data-driven reference region for assessing 4R tau in PSP.Dynamic [18F]PI-2620 PET (60 min) was acquired in 58 PSP-Richardson Syndrome (PSP-RS) and 18 healthy controls (HC). IDIF-modelling with carotid timeseries derived total distribution volume (VT). Iteratively normalizing VT images to atlas-based white matter (WM), we identified reference candidates maximizing PSP-RS vs. HC pallidum differences. The best-performing WM references were combined to a temporo-orbital WM reference, validated in PSP-nonRS (n = 54), HC (n = 18), and disease controls (α-synucleinopathies, n = 21; Alzheimer’s disease (AD, n = 22) using VT-ratios (VTr) and 20-40min static standardized uptake value ratios (SUVr).Using the data-driven temporo-orbital WM reference, PSP patients showed significantly higher basal ganglia [18F]PI-2620 signal vs. HC compared to cerebellar normalization. Receiver operating curve (ROC) analysis confirmed higher diagnostic accuracy using the temporo-orbital WM reference. Pallidum [18F]PI-2620 showed significant associations with clinical disease severity exclusively when using the novel temporo-orbital WM reference.A data-driven temporo-orbital WM reference optimizes [18F]PI-2620 PET assessment for PSP diagnosis, outperforming conventional cerebellar references used in tau-PET imaging.The online version contains supplementary material available at 10.1007/s00259-025-07396-8. |
| 536 | _ | _ | |a 352 - Disease Mechanisms (POF4-352) |0 G:(DE-HGF)POF4-352 |c POF4-352 |f POF IV |x 0 |
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| 650 | _ | 7 | |a Four-repeat tauopathies |2 Other |
| 650 | _ | 7 | |a Progressive supranuclear palsy |2 Other |
| 650 | _ | 7 | |a Reference region |2 Other |
| 650 | _ | 7 | |a Tau |2 Other |
| 650 | _ | 7 | |a [18F]PI-2620 |2 Other |
| 700 | 1 | _ | |a Gnoerich, Johannes |0 P:(DE-2719)9001652 |b 1 |u dzne |
| 700 | 1 | _ | |a Gross, Mattes |b 2 |
| 700 | 1 | _ | |a Dehsarvi, Amir |b 3 |
| 700 | 1 | _ | |a Roemer-Cassiano, Sebastian N |b 4 |
| 700 | 1 | _ | |a Palleis, Carla |0 P:(DE-2719)9000852 |b 5 |u dzne |
| 700 | 1 | _ | |a Katzdobler, Sabrina |0 P:(DE-2719)9001160 |b 6 |u dzne |
| 700 | 1 | _ | |a Dewenter, Anna |b 7 |
| 700 | 1 | _ | |a Steward, Anna |b 8 |
| 700 | 1 | _ | |a Biel, Davina |b 9 |
| 700 | 1 | _ | |a Hirsch, Fabian |b 10 |
| 700 | 1 | _ | |a Zhu, Zeyu |b 11 |
| 700 | 1 | _ | |a Levin, Johannes |0 P:(DE-2719)2811659 |b 12 |u dzne |
| 700 | 1 | _ | |a Stephens, Andrew W |b 13 |
| 700 | 1 | _ | |a Müller, Andre |b 14 |
| 700 | 1 | _ | |a Koglin, Norman |b 15 |
| 700 | 1 | _ | |a Bischof, Gérard N |0 P:(DE-2719)9002485 |b 16 |
| 700 | 1 | _ | |a Kovacs, Gabor G |b 17 |
| 700 | 1 | _ | |a Höglinger, Günter U |0 P:(DE-2719)2811373 |b 18 |u dzne |
| 700 | 1 | _ | |a Brendel, Matthias |0 P:(DE-2719)9001539 |b 19 |e Last author |u dzne |
| 700 | 1 | _ | |a Franzmeier, Nicolai |b 20 |
| 773 | _ | _ | |a 10.1007/s00259-025-07396-8 |g Vol. 52, no. 13, p. 5098 - 5112 |0 PERI:(DE-600)2098375-X |n 13 |p 5098 - 5112 |t European journal of nuclear medicine and molecular imaging |v 52 |y 2025 |x 1619-7070 |
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