000283024 001__ 283024
000283024 005__ 20251222101459.0
000283024 0247_ $$2doi$$a10.1126/scitranslmed.adv3260
000283024 0247_ $$2pmid$$apmid:40961224
000283024 0247_ $$2ISSN$$a1946-6234
000283024 0247_ $$2ISSN$$a1946-6242
000283024 037__ $$aDZNE-2025-01436
000283024 041__ $$aEnglish
000283024 082__ $$a500
000283024 1001_ $$00009-0003-8113-7200$$aMitlasóczki, Bence$$b0
000283024 245__ $$aHippocampal spreading depolarization as a driver of postictal ambulation.
000283024 260__ $$aWashington, DC$$bAAAS$$c2025
000283024 3367_ $$2DRIVER$$aarticle
000283024 3367_ $$2DataCite$$aOutput Types/Journal article
000283024 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1766394516_14398
000283024 3367_ $$2BibTeX$$aARTICLE
000283024 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000283024 3367_ $$00$$2EndNote$$aJournal Article
000283024 520__ $$aPostseizure (postictal) symptoms are regularly encountered in epilepsy and can be life threatening, yet their neurobiological underpinnings remain understudied. Using two-photon or widefield imaging, field potential and unit recordings, optogenetics, and basic behavioral assessment under healthy conditions or viral encephalitis, we studied seizures and postictal symptoms in mice. We show a propensity of the hippocampus for seizure-associated spreading depolarization (sSD). Through optogenetic stimulation, we provide evidence that induced isolated hippocampal SD is sufficient to elicit postictal ambulation (PIA), whereas induced isolated seizure-like episodes are not. Furthermore, PIA occurred in the absence of SD progression to the neocortex. In addition, we analyzed Behnke-Fried depth-electrode recordings in four patients with focal epilepsy. Of 13 recorded seizures, we observed five slow shifts at seizure termination in the regionwise analysis that could reflect putative sSD. In support of our experiments in mice, we also found an increased vulnerability of the human temporomesial system (hippocampus and amygdala) for this phenomenon and longer recovery times of affected as compared with nonaffected brain regions. This work suggests sSD as a previously underrecognized pathoclinical entity underlying distinct postictal symptoms in epilepsy.
000283024 536__ $$0G:(DE-HGF)POF4-899$$a899 - ohne Topic (POF4-899)$$cPOF4-899$$fPOF IV$$x0
000283024 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000283024 650_2 $$2MeSH$$aAnimals
000283024 650_2 $$2MeSH$$aHippocampus: physiopathology
000283024 650_2 $$2MeSH$$aHumans
000283024 650_2 $$2MeSH$$aSeizures: physiopathology
000283024 650_2 $$2MeSH$$aMale
000283024 650_2 $$2MeSH$$aFemale
000283024 650_2 $$2MeSH$$aWalking: physiology
000283024 650_2 $$2MeSH$$aMice
000283024 650_2 $$2MeSH$$aMice, Inbred C57BL
000283024 650_2 $$2MeSH$$aOptogenetics
000283024 650_2 $$2MeSH$$aElectroencephalography
000283024 650_2 $$2MeSH$$aAdult
000283024 7001_ $$aGutiérrez Gómez, Adrián$$b1
000283024 7001_ $$aKamali, Midia$$b2
000283024 7001_ $$aBabushkina, Natalia$$b3
000283024 7001_ $$aBaues, Mayan$$b4
000283024 7001_ $$aKück, Laura$$b5
000283024 7001_ $$aHaubrich, André Nathan$$b6
000283024 7001_ $$aTamiolakis, Theodoros$$b7
000283024 7001_ $$0P:(DE-2719)9000501$$aBreuer, Annika$$b8
000283024 7001_ $$00000-0002-1037-5506$$aGranak, Simon$$b9
000283024 7001_ $$aSchwering-Sohnrey, Merlin$$b10
000283024 7001_ $$00000-0002-7973-7405$$aGerhauser, Ingo$$b11
000283024 7001_ $$00000-0001-8151-5644$$aBaumgärtner, Wolfgang$$b12
000283024 7001_ $$aSchwarz, Martin Karl$$b13
000283024 7001_ $$00000-0002-1638-426X$$aEwell, Laura$$b14
000283024 7001_ $$0P:(DE-2719)9000241$$aOpitz, Thoralf$$b15
000283024 7001_ $$00000-0002-6688-4916$$aPitsch, Julika$$b16
000283024 7001_ $$00000-0002-9461-1042$$aMusall, Simon$$b17
000283024 7001_ $$00000-0002-3177-8582$$aSurges, Rainer$$b18
000283024 7001_ $$0P:(DE-2719)9000221$$aMormann, Florian$$b19
000283024 7001_ $$0P:(DE-2719)2000044$$aBeck, Heinz$$b20
000283024 7001_ $$00000-0002-6065-1660$$aWenzel, Michael$$b21
000283024 773__ $$0PERI:(DE-600)2518839-2$$a10.1126/scitranslmed.adv3260$$gVol. 17, no. 816, p. eadv3260$$n816$$peadv3260$$tScience translational medicine$$v17$$x1946-6234$$y2025
000283024 8564_ $$uhttps://pub.dzne.de/record/283024/files/DZNE-2025-1436_Restricted.pdf
000283024 8564_ $$uhttps://pub.dzne.de/record/283024/files/DZNE-2025-1436_Restricted.pdf?subformat=pdfa$$xpdfa
000283024 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000044$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b20$$kDZNE
000283024 9131_ $$0G:(DE-HGF)POF4-899$$1G:(DE-HGF)POF4-890$$2G:(DE-HGF)POF4-800$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vohne Topic$$x0
000283024 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-20
000283024 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-20
000283024 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-20
000283024 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-20
000283024 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-20
000283024 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-20
000283024 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-20
000283024 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-20
000283024 9201_ $$0I:(DE-2719)6000011$$kBonn common$$lBonn common$$x0
000283024 980__ $$ajournal
000283024 980__ $$aEDITORS
000283024 980__ $$aVDBINPRINT
000283024 980__ $$aI:(DE-2719)6000011
000283024 980__ $$aUNRESTRICTED