000283025 001__ 283025
000283025 005__ 20251222101655.0
000283025 0247_ $$2doi$$a10.1002/alz.70695
000283025 0247_ $$2pmid$$apmid:41057914
000283025 0247_ $$2pmc$$apmc:PMC12504049
000283025 0247_ $$2ISSN$$a1552-5260
000283025 0247_ $$2ISSN$$a1552-5279
000283025 037__ $$aDZNE-2025-01437
000283025 041__ $$aEnglish
000283025 082__ $$a610
000283025 1001_ $$aSoltaninejad, Mahdie$$b0
000283025 245__ $$aWhite matter hyperintensities precede other biomarkers in GRN frontotemporal dementia.
000283025 260__ $$aHoboken, NJ$$bWiley$$c2025
000283025 3367_ $$2DRIVER$$aarticle
000283025 3367_ $$2DataCite$$aOutput Types/Journal article
000283025 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1766394857_14401
000283025 3367_ $$2BibTeX$$aARTICLE
000283025 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000283025 3367_ $$00$$2EndNote$$aJournal Article
000283025 520__ $$aIncreased white matter hyperintensities (WMHs) have been reported in genetic frontotemporal dementia (FTD) in small studies, but the sequence of WMH abnormalities relative to other biomarkers is unclear.Using a large dataset (n = 763 GENFI2 participants), we measured WMHs and examined them across genetic FTD variants and stages. Cortical and subcortical volumes were parcellated, and serum neurofilament light chain (NfL) levels were measured. Biomarker progression was assessed with discriminative event-based and regression modeling.Symptomatic GRN carriers showed elevated WMHs, primarily in the frontal lobe, while no significant increase was observed in symptomatic C9orf72 or MAPT carriers. WMH abnormalities preceded NfL elevation, ventricular enlargement, and cortical atrophy. Longitudinally, baseline WMHs predicted subcortical changes, while subcortical volumes did not predict WMH changes, suggesting WMHs may precede neurodegeneration.WMHs are elevated in a subset of GRN-associated FTD. When present, they appear early and should be considered in disease progression models.Elevated WMH volumes are found predominantly in symptomatic GRN. WMH accumulation is mostly observed in the frontal lobe. WMH abnormalities appear early in GRN-associated FTD, before NfL, atrophy, and ventriculomegaly. Longitudinally, WMH volumes can predict subcortical changes, but not vice versa. WMHs are key early markers in GRN-associated FTD and should be included in progression models.
000283025 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000283025 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000283025 650_7 $$2Other$$aC9orf72
000283025 650_7 $$2Other$$aFTD
000283025 650_7 $$2Other$$aGRN
000283025 650_7 $$2Other$$aMAPT
000283025 650_7 $$2Other$$abiomarker sequence
000283025 650_7 $$2Other$$adementia
000283025 650_7 $$2Other$$adisease progression
000283025 650_7 $$2Other$$aearly marker
000283025 650_7 $$2Other$$aevent‐based modeling
000283025 650_7 $$2Other$$amagnetic resonance imaging
000283025 650_7 $$2Other$$aneurodegeneration
000283025 650_7 $$2Other$$aneurofilament light chain
000283025 650_7 $$2Other$$aneuroimaging
000283025 650_7 $$2Other$$aprogranulin
000283025 650_7 $$2Other$$awhite matter
000283025 650_7 $$2NLM Chemicals$$aBiomarkers
000283025 650_7 $$2NLM Chemicals$$aProgranulins
000283025 650_7 $$2NLM Chemicals$$aGRN protein, human
000283025 650_7 $$2NLM Chemicals$$aC9orf72 Protein
000283025 650_7 $$2NLM Chemicals$$aNeurofilament Proteins
000283025 650_7 $$2NLM Chemicals$$aneurofilament protein L
000283025 650_7 $$2NLM Chemicals$$atau Proteins
000283025 650_7 $$2NLM Chemicals$$aC9orf72 protein, human
000283025 650_7 $$2NLM Chemicals$$aMAPT protein, human
000283025 650_2 $$2MeSH$$aHumans
000283025 650_2 $$2MeSH$$aFrontotemporal Dementia: genetics
000283025 650_2 $$2MeSH$$aFrontotemporal Dementia: pathology
000283025 650_2 $$2MeSH$$aFrontotemporal Dementia: diagnostic imaging
000283025 650_2 $$2MeSH$$aWhite Matter: pathology
000283025 650_2 $$2MeSH$$aWhite Matter: diagnostic imaging
000283025 650_2 $$2MeSH$$aMale
000283025 650_2 $$2MeSH$$aFemale
000283025 650_2 $$2MeSH$$aBiomarkers: blood
000283025 650_2 $$2MeSH$$aProgranulins: genetics
000283025 650_2 $$2MeSH$$aMiddle Aged
000283025 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000283025 650_2 $$2MeSH$$aC9orf72 Protein: genetics
000283025 650_2 $$2MeSH$$aNeurofilament Proteins: blood
000283025 650_2 $$2MeSH$$aAged
000283025 650_2 $$2MeSH$$aDisease Progression
000283025 650_2 $$2MeSH$$atau Proteins: genetics
000283025 650_2 $$2MeSH$$aAtrophy
000283025 7001_ $$aDadar, Mahsa$$b1
000283025 7001_ $$aCollins, D Louis$$b2
000283025 7001_ $$aRajabli, Reza$$b3
000283025 7001_ $$aVenkatraghavan, Vikram$$b4
000283025 7001_ $$aBouzigues, Arabella$$b5
000283025 7001_ $$aRussell, Lucy L$$b6
000283025 7001_ $$aFoster, Phoebe H$$b7
000283025 7001_ $$aFerry-Bolder, Eve$$b8
000283025 7001_ $$avan Swieten, John C$$b9
000283025 7001_ $$aJiskoot, Lize C$$b10
000283025 7001_ $$aSeelaar, Harro$$b11
000283025 7001_ $$aSanchez-Valle, Raquel$$b12
000283025 7001_ $$aLaforce, Robert$$b13
000283025 7001_ $$aGraff, Caroline$$b14
000283025 7001_ $$aGalimberti, Daniela$$b15
000283025 7001_ $$aVandenberghe, Rik$$b16
000283025 7001_ $$ade Mendonça, Alexandre$$b17
000283025 7001_ $$aTiraboschi, Pietro$$b18
000283025 7001_ $$aSantana, Isabel$$b19
000283025 7001_ $$aGerhard, Alexander$$b20
000283025 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b21$$udzne
000283025 7001_ $$aNacmias, Benedetta$$b22
000283025 7001_ $$aOtto, Markus$$b23
000283025 7001_ $$aBertoux, Maxime$$b24
000283025 7001_ $$aLebouvier, Thibaud$$b25
000283025 7001_ $$aButler, Chris R$$b26
000283025 7001_ $$aBer, Isabelle Le$$b27
000283025 7001_ $$aFinger, Elizabeth$$b28
000283025 7001_ $$aTartaglia, Maria Carmela$$b29
000283025 7001_ $$aMasellis, Mario$$b30
000283025 7001_ $$aRowe, James B$$b31
000283025 7001_ $$0P:(DE-2719)2811275$$aSynofzik, Matthis$$b32$$udzne
000283025 7001_ $$aMoreno, Fermin$$b33
000283025 7001_ $$aBorroni, Barbara$$b34
000283025 7001_ $$aRohrer, Jonathan D$$b35
000283025 7001_ $$aIturria-Medina, Yasser$$b36
000283025 7001_ $$aDucharme, Simon$$b37
000283025 7001_ $$aConsortium, GENFI$$b38$$eCollaboration Author
000283025 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.70695$$gVol. 21, no. 10, p. e70695$$n10$$pe70695$$tAlzheimer's and dementia$$v21$$x1552-5260$$y2025
000283025 8564_ $$uhttps://pub.dzne.de/record/283025/files/DZNE-2025-1437.pdf$$yRestricted
000283025 8564_ $$uhttps://pub.dzne.de/record/283025/files/DZNE-2025-1437.pdf?subformat=pdfa$$xpdfa$$yRestricted
000283025 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811659$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b21$$kDZNE
000283025 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811275$$aExternal Institute$$b32$$kExtern
000283025 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000283025 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2025-01-06$$wger
000283025 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bALZHEIMERS DEMENT : 2022$$d2025-01-06
000283025 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2025-01-06
000283025 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2025-01-06
000283025 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2025-01-06
000283025 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2025-01-06
000283025 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2025-01-06
000283025 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2025-01-06
000283025 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2025-01-06
000283025 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bALZHEIMERS DEMENT : 2022$$d2025-01-06
000283025 9201_ $$0I:(DE-2719)1111015$$kClinical Research (Munich)$$lClinical Research (Munich)$$x0
000283025 9201_ $$0I:(DE-2719)1111016$$kAG Levin$$lClinical Neurodegeneration$$x1
000283025 980__ $$ajournal
000283025 980__ $$aEDITORS
000283025 980__ $$aVDBINPRINT
000283025 980__ $$aI:(DE-2719)1111015
000283025 980__ $$aI:(DE-2719)1111016
000283025 980__ $$aUNRESTRICTED