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| 001 | 283031 | ||
| 005 | 20251222132504.0 | ||
| 037 | _ | _ | |a DZNE-2025-01443 |
| 100 | 1 | _ | |a Chhabra, Akshita |0 P:(DE-2719)9002015 |b 0 |u dzne |
| 245 | _ | _ | |a Condensates of synaptic vesicles and synapsin-1 mediate actin polymerization |
| 260 | _ | _ | |c 2025 |b BioStudies |
| 336 | 7 | _ | |a MISC |2 BibTeX |
| 336 | 7 | _ | |a Dataset |b dataset |m dataset |0 PUB:(DE-HGF)32 |s 1766405824_14400 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Chart or Table |0 26 |2 EndNote |
| 336 | 7 | _ | |a Dataset |2 DataCite |
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| 336 | 7 | _ | |a ResearchData |2 DINI |
| 500 | _ | _ | |a Deutsche Forschungsgemeinschaft (DFG): MI 2104 SFB 1286/B10 SFB 1286/B02 SFB 1286/B02EC | ERC | HORIZON EUROPE European Research Council (ERC): 101078172HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS): NS078165-12 NS126575-01Deutsche Demenzhilfe: Innovative Minds ProgramGerman Academic Scholarship Foundation: N/A |
| 520 | _ | _ | |a Neuronal communication relies on precisely maintained synaptic vesicle (SV) clusters, which assemble via liquid-liquid phase separation. This process requires synapsins, the major synaptic phosphoproteins, which are known to bind actin. Reorganization of SVs, synapsins, and actin is a hallmark of synaptic activity, but the molecular details of the interactions between these components remain unclear. Here, we combine in vitro reconstitution with expansion microscopy, super-resolution imaging, and cryo-electron tomography to dissect the roles of SV-synapsin-1 condensates in the organization of the presynaptic actin cytoskeleton. Our results indicate that condensation of synapsin-1 initiates actin polymerization. This process enables SV-synapsin-actin assemblies to facilitate the mesoscale organization of SV clusters along axons, which is similar to the native presynaptic organization observed at both lamprey and mammalian synapses. Understanding the relationship between the actin network and synapsin-synaptic vesicle condensates can help elucidate how coordinated neurotransmission along the axon enables circuit function and behavior. |
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| 700 | 1 | _ | |a Hoffmann, Christian |0 P:(DE-2719)9000582 |b 1 |u dzne |
| 700 | 1 | _ | |a Aguilar Perez, Gerard |0 P:(DE-2719)9002012 |b 2 |u dzne |
| 700 | 1 | _ | |a Korobeinikov, Aleksandr |0 P:(DE-2719)9002676 |b 3 |u dzne |
| 700 | 1 | _ | |a Rentsch, Jakob |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Hümpfer, Nadja |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Kokwaro, Linda |0 P:(DE-2719)9001437 |b 6 |
| 700 | 1 | _ | |a Gnidovec, Luka |0 P:(DE-2719)9002532 |b 7 |u dzne |
| 700 | 1 | _ | |a Petrovic, Arsen |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Wallace, Jaqulin |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Tromm, Johannes Vincent |0 P:(DE-2719)9002092 |b 10 |u dzne |
| 700 | 1 | _ | |a Roman-Vendrell, Cristina |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a Johnson, Emma |0 P:(DE-HGF)0 |b 12 |
| 700 | 1 | _ | |a Rankovic, Branislava |0 P:(DE-2719)9001749 |b 13 |u dzne |
| 700 | 1 | _ | |a Perego, Eleonora |0 P:(DE-HGF)0 |b 14 |
| 700 | 1 | _ | |a Volpi, Tommaso |0 P:(DE-HGF)0 |b 15 |
| 700 | 1 | _ | |a Fernandez-Busnadiego, Ruben |0 P:(DE-HGF)0 |b 16 |
| 700 | 1 | _ | |a Köster, Sarah |0 P:(DE-HGF)0 |b 17 |
| 700 | 1 | _ | |a Rizzoli, Silvio |0 P:(DE-HGF)0 |b 18 |
| 700 | 1 | _ | |a Ewers, Helge |0 P:(DE-HGF)0 |b 19 |
| 700 | 1 | _ | |a Morgan, Jennifer |0 P:(DE-HGF)0 |b 20 |
| 700 | 1 | _ | |a Milovanovic, Dragomir |0 P:(DE-2719)9000670 |b 21 |e Last author |u dzne |
| 787 | 0 | _ | |a Chhabra, Akshita et.al. |d [London] : Nature Publishing Group UK, 2025 |i RelatedTo |0 DZNE-2025-01105 |r |t Condensates of synaptic vesicles and synapsin-1 mediate actin sequestering and polymerization. |
| 856 | 4 | _ | |u https://www.ebi.ac.uk/biostudies/sourcedata/studies/S-SCDT-10_1038-S44318-025-00516-y |
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| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-351 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Brain Function |x 0 |
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