Home > Publications Database > Uncovering hypothalamic network disruption in ALS. > print

001     283047
005     20260225154718.0
024 7 _ |2 doi
|a 10.1007/s00415-025-13574-3
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|a pmid:41428120
024 7 _ |2 pmc
|a pmc:PMC12722382
024 7 _ |2 ISSN
|a 0367-004X
024 7 _ |2 ISSN
|a 0012-1037
024 7 _ |2 ISSN
|a 0340-5354
024 7 _ |2 ISSN
|a 1432-1459
037 _ _ |a DZNE-2025-01454
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Freri, Fabiola
|b 0
245 _ _ |a Uncovering hypothalamic network disruption in ALS.
260 _ _ |a [Darmstadt]
|b Steinkopff
|c 2026
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520 _ _ |a Structural MRI studies have shown hypothalamic atrophy and altered white matter (WM) connectivity in amyotrophic lateral sclerosis (ALS), as a possible substrate of hypermetabolism in this condition. However, hypothalamic functional connectivity and its association with clinical features in ALS remain unclear. This study explored hypothalamic resting-state functional connectivity (RS-FC) in ALS patients compared to controls and its relationship with disease severity defined by the ALS Functional Rating Scale (ALSFRS-r), body mass index (BMI), disease duration, progression rate, survival, hypothalamic volume, and WM integrity.Seventy-one ALS patients and 39 healthy controls underwent structural and RS functional MRI. The bilateral hypothalamus was segmented, and a seed-based RS-FC analysis was performed. Group differences in hypothalamic RS-FC and their correlations with ALSFRS-r scores, BMI, disease duration, progression rate, survival, hypothalamic volume, and WM integrity were assessed. Tract-based spatial statistics was performed to estimate the correlation between WM damage in ALS and hypothalamic RS-FC.ALS patients showed increased hypothalamic RS-FC with caudate nuclei compared to controls. Additionally, greater disease severity correlated with increased hypothalamic RS-FC with the caudate nuclei and orbitofrontal cortex. Hypothalamic RS-FC mean values also associated with FA in the genu of corpus callosum and forceps minor and disease progression rate. No significant correlations were observed with other clinical features.These findings support hypothalamic alterations in ALS. Early detection of hypothalamic changes could be useful in prognostic stratification and evaluating intervention effects.
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650 _ 7 |2 Other
|a Amyotrophic lateral sclerosis
650 _ 7 |2 Other
|a Functional connectivity
650 _ 7 |2 Other
|a Hypermetabolism
650 _ 7 |2 Other
|a Hypothalamus
650 _ 7 |2 Other
|a MRI
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Amyotrophic Lateral Sclerosis: diagnostic imaging
650 _ 2 |2 MeSH
|a Amyotrophic Lateral Sclerosis: physiopathology
650 _ 2 |2 MeSH
|a Amyotrophic Lateral Sclerosis: pathology
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Middle Aged
650 _ 2 |2 MeSH
|a Hypothalamus: diagnostic imaging
650 _ 2 |2 MeSH
|a Hypothalamus: physiopathology
650 _ 2 |2 MeSH
|a Hypothalamus: pathology
650 _ 2 |2 MeSH
|a Magnetic Resonance Imaging
650 _ 2 |2 MeSH
|a Aged
650 _ 2 |2 MeSH
|a Adult
650 _ 2 |2 MeSH
|a White Matter: diagnostic imaging
650 _ 2 |2 MeSH
|a White Matter: pathology
650 _ 2 |2 MeSH
|a Nerve Net: diagnostic imaging
650 _ 2 |2 MeSH
|a Nerve Net: physiopathology
650 _ 2 |2 MeSH
|a Disease Progression
650 _ 2 |2 MeSH
|a Connectome
700 1 _ |a Spinelli, Edoardo Gioele
|b 1
700 1 _ |a Canu, Elisa
|b 2
700 1 _ |a Basaia, Silvia
|b 3
700 1 _ |a Castelnovo, Veronica
|b 4
700 1 _ |0 P:(DE-HGF)0
|a Müller, Hans-Peter
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700 1 _ |0 P:(DE-2719)9001967
|a Kassubek, Jan
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|a Ludolph, Albert C
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700 1 _ |a Krishnamurthy, Sruthi Sankari
|b 8
700 1 _ |0 P:(DE-2719)2812851
|a Roselli, Francesco
|b 9
|u dzne
700 1 _ |a Filippi, Massimo
|b 10
700 1 _ |0 0000-0003-3121-4979
|a Agosta, Federica
|b 11
773 _ _ |0 PERI:(DE-600)1421299-7
|a 10.1007/s00415-025-13574-3
|g Vol. 273, no. 1, p. 37
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|t Journal of neurology
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|x 0367-004X
|y 2026
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