TY  - JOUR
AU  - Cai, Mengfei
AU  - Li, Hao
AU  - Nemy, Milan
AU  - Jacob, Mina A
AU  - Norris, David G
AU  - Duering, Marco
AU  - Zhang, Yuhu
AU  - Kessels, Roy P C
AU  - Vyslouzilova, Lenka
AU  - Teipel, Stefan J
AU  - Ferreira, Daniel
AU  - de Leeuw, Frank-Erik
AU  - Tuladhar, Anil M
TI  - Cholinergic Disruption Contributes to Motoric Cognitive Dysfunction in Cerebral Small Vessel Disease.
JO  - Stroke
VL  - 57
IS  - 1
SN  - 0039-2499
CY  - New York, NY
PB  - Association
M1  - DZNE-2025-01457
SP  - 169 - 181
PY  - 2026
AB  - Cognitive decline and gait disturbance are often observed simultaneously in patients with small vessel disease (SVD), also known as motoric cognitive dysfunction. However, it remains unknown whether cholinergic system disruption contributes to motoric cognitive dysfunction.In this cross-sectional, single-center study conducted in the Netherlands, we included 213 patients with SVD between 2020 and 2021, all of whom had multimodal magnetic resonance imaging scans, gait assessments using the 6-meter walk test, and cognitive test battery data available. Cholinergic cortical (through external capsule and cingulum) and thalamic projections (pedunculopontine nucleus to thalamus) were reconstructed using probabilistic tractography on diffusion images, followed by the quantification of the disruption in these tracts with diffusion metrics derived from neurite orientation dispersion and density imaging model. Conventional magnetic resonance imaging markers for SVD were assessed.Covariates, including neurite orientation dispersion and density imaging metrics in the white matter control mask and SVD markers, were adjusted in linear regression.A total of 213 patients with SVD were included, with a mean (SD) age of 74.6 (6.8) years, of whom 96 (45.1
KW  - Humans
KW  - Cerebral Small Vessel Diseases: diagnostic imaging
KW  - Cerebral Small Vessel Diseases: complications
KW  - Cerebral Small Vessel Diseases: physiopathology
KW  - Female
KW  - Male
KW  - Aged
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Cognitive Dysfunction: etiology
KW  - Cognitive Dysfunction: physiopathology
KW  - Cross-Sectional Studies
KW  - Aged, 80 and over
KW  - White Matter: diagnostic imaging
KW  - Middle Aged
KW  - Magnetic Resonance Imaging
KW  - Diffusion Tensor Imaging
KW  - cerebral small vessel diseases (Other)
KW  - cognition (Other)
KW  - cognitive dysfunction (Other)
KW  - gait (Other)
KW  - neuroimaging (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41164858
DO  - DOI:10.1161/STROKEAHA.125.052256
UR  - https://pub.dzne.de/record/283050
ER  -