TY  - JOUR
AU  - Bartels, Frederik
AU  - Tapuc, Andreea
AU  - Rentzsch, Kristin
AU  - Duong, Sophie L
AU  - Prüss, Harald
AU  - Finke, Carsten
TI  - Memory Deficits in Cancer Patients With Serum NMDA Receptor Autoantibodies.
JO  - Neurology
VL  - 106
IS  - 2
SN  - 0028-3878
CY  - Philadelphia, Pa.
PB  - Wolters Kluwer
M1  - DZNE-2025-01458
SP  - e214490
PY  - 2026
AB  - Neuronal autoantibodies are linked to cognitive impairment in neurologic diseases and can be associated with tumors. In patients with cancer, IgA/IgM N-Methyl-D-Aspartate receptor (NMDAR) autoantibodies are most common, yet their clinical relevance is unclear. We assessed cognitive function in cancer patients with serum NMDAR autoantibodies and compared the results with matched controls.For this cross-sectional case-control study in Germany, we recruited 1,055 patients with cancer and tested for neuronal serum autoantibodies. Cognitive assessment was performed blinded to antibody status and after excluding patients with potential confounders of cognitive dysfunction. The tests included verbal memory (Rey Auditory Verbal Learning Test), visuospatial memory (Rey-Osterrieth Complex Figure), and working memory.Fifty-six patients with IgA/IgM NMDAR autoantibodies (median age 61.0 years [28.0-86.0], 35.7
KW  - Humans
KW  - Female
KW  - Male
KW  - Autoantibodies: blood
KW  - Middle Aged
KW  - Receptors, N-Methyl-D-Aspartate: immunology
KW  - Aged
KW  - Cross-Sectional Studies
KW  - Case-Control Studies
KW  - Adult
KW  - Memory Disorders: blood
KW  - Memory Disorders: immunology
KW  - Memory Disorders: etiology
KW  - Neoplasms: blood
KW  - Neoplasms: complications
KW  - Neoplasms: immunology
KW  - Neoplasms: psychology
KW  - Aged, 80 and over
KW  - Neuropsychological Tests
KW  - Autoantibodies (NLM Chemicals)
KW  - Receptors, N-Methyl-D-Aspartate (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41453122
DO  - DOI:10.1212/WNL.0000000000214490
UR  - https://pub.dzne.de/record/283051
ER  -