% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Bartels:283051,
      author       = {Bartels, Frederik and Tapuc, Andreea and Rentzsch, Kristin
                      and Duong, Sophie L and Prüss, Harald and Finke, Carsten},
      title        = {{M}emory {D}eficits in {C}ancer {P}atients {W}ith {S}erum
                      {NMDA} {R}eceptor {A}utoantibodies.},
      journal      = {Neurology},
      volume       = {106},
      number       = {2},
      issn         = {0028-3878},
      address      = {Philadelphia, Pa.},
      publisher    = {Wolters Kluwer},
      reportid     = {DZNE-2025-01458},
      pages        = {e214490},
      year         = {2026},
      abstract     = {Neuronal autoantibodies are linked to cognitive impairment
                      in neurologic diseases and can be associated with tumors. In
                      patients with cancer, IgA/IgM N-Methyl-D-Aspartate receptor
                      (NMDAR) autoantibodies are most common, yet their clinical
                      relevance is unclear. We assessed cognitive function in
                      cancer patients with serum NMDAR autoantibodies and compared
                      the results with matched controls.For this cross-sectional
                      case-control study in Germany, we recruited 1,055 patients
                      with cancer and tested for neuronal serum autoantibodies.
                      Cognitive assessment was performed blinded to antibody
                      status and after excluding patients with potential
                      confounders of cognitive dysfunction. The tests included
                      verbal memory (Rey Auditory Verbal Learning Test),
                      visuospatial memory (Rey-Osterrieth Complex Figure), and
                      working memory.Fifty-six patients with IgA/IgM NMDAR
                      autoantibodies (median age 61.0 years [28.0-86.0], $35.7\%$
                      female) were matched 1:1 to autoantibody-negative patients
                      by age, sex, cancer type, and stage. Autoantibody-positive
                      patients showed impairments in verbal memory (mean score ±
                      SD: 9.7 ± 3.6 vs 11.4 ± 3.2; p = 0.01; Cohen d = 0.49),
                      visuospatial memory (19.4 ± 7.0 vs 22.6 ± 5.6; p = 0.01; d
                      = 0.50), and working memory (6.2 ± 1.9 vs 7.0 ± 2.1; p =
                      0.04; d = 0.40). Memory function decreased with increasing
                      IgA NMDAR autoantibody levels. Both groups performed
                      similarly on measures of attention, executive function, and
                      verbal fluency.Serum NMDAR autoantibodies are associated
                      with isolated memory deficits in patients with cancer and
                      might serve as a potential biomarker for cancer-related
                      cognitive impairment.},
      keywords     = {Humans / Female / Male / Autoantibodies: blood / Middle
                      Aged / Receptors, N-Methyl-D-Aspartate: immunology / Aged /
                      Cross-Sectional Studies / Case-Control Studies / Adult /
                      Memory Disorders: blood / Memory Disorders: immunology /
                      Memory Disorders: etiology / Neoplasms: blood / Neoplasms:
                      complications / Neoplasms: immunology / Neoplasms:
                      psychology / Aged, 80 and over / Neuropsychological Tests /
                      Autoantibodies (NLM Chemicals) / Receptors,
                      N-Methyl-D-Aspartate (NLM Chemicals)},
      cin          = {AG Prüß},
      ddc          = {610},
      cid          = {I:(DE-2719)1810003},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41453122},
      doi          = {10.1212/WNL.0000000000214490},
      url          = {https://pub.dzne.de/record/283051},
}