TY  - CONF
AU  - Boscheck, Hanna
AU  - Liebscher, Maxie
AU  - Delia, Ylenia
AU  - Mauer, René
AU  - Peters, Oliver
AU  - Priller, Josef
AU  - Schneider, Anja
AU  - Wiltfang, Jens
AU  - Buerger, Katharina
AU  - Perneczky, Robert
AU  - Teipel, Stefan
AU  - Laske, Christoph
AU  - Spottke, Annika
AU  - Brosseron, Frederic
AU  - Yakupov, Renat
AU  - Ziegler, Gabriel
AU  - Kleineidam, Luca
AU  - Jessen, Frank
AU  - Düzel, Emrah
AU  - Wagner, Michael
AU  - Roeske, Sandra
AU  - Marchant, Natalie L
AU  - Gloeckner, Franka
AU  - Klimecki-Lenz, Olga Maria
AU  - Wirth, Miranka
TI  - Associations of cognitive debt and cognitive reserve with mixed brain pathology and cognition
JO  - Alzheimer's and dementia
VL  - 21
IS  - Suppl 2
SN  - 1552-5260
M1  - DZNE-2025-01460
SP  - e102595
PY  - 2025
AB  - Behavioral risk or protective factors related to 'cognitive debt' and 'cognitive reserve' may influence brain pathology and cognition and thereby contribute to resilience in aging. This cross-sectional study examined direct and indirect associations of cognitive debt (risk factor) and cognitive reserve (protective factor) with mixed brain pathologies and cognition in older adults.A sample of N = 298 non-demented older adults (mean age=70 years, 56
T2  - Alzheimer’s Association International Conference
CY  - 27 Jul 2025 - 31 Jul 2025, Toronto (Canada)
Y2  - 27 Jul 2025 - 31 Jul 2025
M2  - Toronto, Canada
KW  - Humans
KW  - Male
KW  - Aged
KW  - Female
KW  - Cross-Sectional Studies
KW  - Biomarkers
KW  - Cognitive Reserve: physiology
KW  - Brain: pathology
KW  - Amyloid beta-Peptides: metabolism
KW  - Neuropsychological Tests
KW  - Magnetic Resonance Imaging
KW  - Alzheimer Disease
KW  - White Matter: pathology
KW  - Hippocampus: pathology
KW  - Aged, 80 and over
KW  - Biomarkers (NLM Chemicals)
KW  - Amyloid beta-Peptides (NLM Chemicals)
LB  - PUB:(DE-HGF)1 ; PUB:(DE-HGF)16
C6  - pmid:41450093
C2  - pmc:PMC12741494
DO  - DOI:10.1002/alz70856_102595
UR  - https://pub.dzne.de/record/283053
ER  -