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@INPROCEEDINGS{Jeran:283054,
      author       = {Jeran, Lina Charlotte and Blecha, Nadia and Thyrian, Jochen
                      René and Hoffmann, Wolfgang and Blotenberg, Iris},
      title        = {{T}he {R}ole of {P}sychosocial {F}actors for {D}epressive
                      {S}ymptoms in {C}aregivers of {P}eople with {D}ementia},
      journal      = {Alzheimer's and dementia},
      volume       = {21 Suppl 4},
      number       = {Suppl 4},
      issn         = {1552-5260},
      reportid     = {DZNE-2025-01461},
      pages        = {e102570},
      year         = {2025},
      abstract     = {Taking care of a person with dementia is challenging and
                      can contribute to depressive symptoms in caregivers. To
                      provide tailored support, predictors of depressive symptoms
                      need to be better understood. Yet, there is a lack of
                      longitudinal studies and little knowledge about the role of
                      psychosocial factors. To address this gap, this study
                      investigates the role of perceived lack of appreciation as
                      well as perceived burden of losing the relationship to the
                      person with dementia on depressive symptoms in caregivers
                      longitudinally - beyond known demographic and clinical
                      predictors.We analyzed data from 179 dyads consisting of
                      people with dementia (Mage = 80, $61.5\%$ female) and their
                      caregivers (Mage = 64.5, $70.9\%$ female) in Germany. Dyads
                      were interviewed annually by specially qualified nurses over
                      a time span of four years. Depressive symptoms of caregivers
                      were assessed with the Patient Health Questionnaire (PHQ),
                      psychosocial factors were assessed using the Berlin
                      Inventory of Caregiver Burden (BIZA-D). We employed a
                      multilevel growth curve model with random intercepts and
                      slopes. We investigated the role of both within- and
                      between-person differences in psychosocial factors for
                      depressive symptoms in caregivers.Perceived lack of
                      appreciation and the perceived burden of losing the
                      relationship to the person with dementia were significant
                      both as within- and between-person differences. The severity
                      of cognitive symptoms in the person with dementia was
                      significant as between- but not within-person difference.
                      Neuropsychiatric symptoms were significant as within- but
                      not between-person difference.For the first time, this study
                      indicates that psychosocial factors play an important role
                      in the development of depressive symptoms in caregivers of
                      people with dementia. Appreciation by the social environment
                      and addressing the changing relationship between the
                      caregiver and the person with dementia might be promising
                      targets for interventions.},
      month         = {Jul},
      date          = {2025-07-27},
      organization  = {Alzheimer’s Association
                       International Conference, Toronto
                       (Canada), 27 Jul 2025 - 31 Jul 2025},
      keywords     = {Humans / Female / Caregivers: psychology / Dementia:
                      psychology / Dementia: nursing / Male / Depression:
                      psychology / Aged / Germany / Middle Aged / Longitudinal
                      Studies / Aged, 80 and over / Surveys and Questionnaires},
      cin          = {AG Thyrian / AG Hoffmann},
      ddc          = {610},
      cid          = {I:(DE-2719)1510800 / I:(DE-2719)1510600},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)1 / PUB:(DE-HGF)16},
      pubmed       = {pmid:41450321},
      pmc          = {pmc:PMC12741729},
      doi          = {10.1002/alz70858_102570},
      url          = {https://pub.dzne.de/record/283054},
}