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000283057 0247_ $$2ISSN$$a1552-5279
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000283057 041__ $$aEnglish
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000283057 1001_ $$0P:(DE-2719)9002772$$aPolk, Sarah E$$b0$$eFirst author
000283057 1112_ $$aAlzheimer’s Association International Conference$$cToronto$$d2025-07-27 - 2025-07-31$$gAAIC 25$$wCanada
000283057 245__ $$aRemote and unsupervised monitoring of episodic memory decline in patients with prodromal Alzheimer's disease
000283057 260__ $$c2025
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000283057 520__ $$aTraditional pen-and-paper neuropsychological assessments are not sensitive to subtle cognitive changes in the earliest stages of Alzheimer's disease (AD), limiting their use for monitoring of cognitive performance over shorter timeframes. Here, we show that frequently administered remote and unsupervised digital cognitive assessments are better suited to capture short-term cognitive decline in early AD.We investigated episodic memory trajectories using self-administered remote digital testing in 202 participants (52-85 years) who completed unsupervised tests for at least 30 weeks. Linear mixed modeling was used to investigate main effects of cognitive status, n = 152 cognitively unimpaired (CU), n = 50 with mild cognitive impairment (MCI), and interaction effects of cognitive status by time spent in the study. Analyses were repeated, stratifying the MCI group by amyloid-β (Aβ) burden (nAβ- = 21, nAβ+ = 24). Baseline and change-change associations with in-person neuropsychological assessments were also examined using Pearson correlations.At baseline, MCI performed worse than CU on an associative memory task (Object-in-Room Recall, ORR), memory precision tasks for objects and scenes (Mnemonic Discrimination Task for Objects and Scenes, MDT-OS), and a familiarity-based memory task (Complex Scene Recognition, CSR). A short-term decline in the familiarity-dependent task was observed in all patients with an MCI diagnosis, while both the familiarity-dependent memory task and memory precision for objects task were sensitive to decline in the MCI Aβ+ group specifically. Change in the remotely assessed familiarity-dependent memory was correlated with multi-year change on annual in-person neuropsychological assessments. Finally, in-person tests were not sensitive to short-term cognitive changes in MCI.Altogether, these findings show that frequent remote cognitive testing is a promising tool to feasibly capture subtle and short-term cognitive decline.
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000283057 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000283057 650_2 $$2MeSH$$aHumans
000283057 650_2 $$2MeSH$$aMale
000283057 650_2 $$2MeSH$$aFemale
000283057 650_2 $$2MeSH$$aNeuropsychological Tests
000283057 650_2 $$2MeSH$$aCognitive Dysfunction: diagnosis
000283057 650_2 $$2MeSH$$aCognitive Dysfunction: psychology
000283057 650_2 $$2MeSH$$aAged
000283057 650_2 $$2MeSH$$aMiddle Aged
000283057 650_2 $$2MeSH$$aAlzheimer Disease: diagnosis
000283057 650_2 $$2MeSH$$aAlzheimer Disease: psychology
000283057 650_2 $$2MeSH$$aAged, 80 and over
000283057 650_2 $$2MeSH$$aMemory, Episodic
000283057 650_2 $$2MeSH$$aAmyloid beta-Peptides
000283057 7001_ $$aClark, Lindsay R$$b1
000283057 7001_ $$aBasche, Kristin E$$b2
000283057 7001_ $$0P:(DE-2719)2812139$$aKleineidam, Luca$$b3
000283057 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b4
000283057 7001_ $$0P:(DE-2719)9001011$$aButryn, Michaela$$b5
000283057 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b6
000283057 7001_ $$0P:(DE-2719)2811351$$aBuerger, Katharina$$b7
000283057 7001_ $$0P:(DE-2719)2811326$$aFliessbach, Klaus$$b8
000283057 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b9
000283057 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b10
000283057 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b11
000283057 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b12
000283057 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan J$$b13
000283057 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b14
000283057 7001_ $$aJohnson, Sterling C$$b15
000283057 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b16
000283057 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b17
000283057 7001_ $$0P:(DE-2719)2812972$$aBerron, David$$b18$$eLast author
000283057 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz70857_106467$$gVol. 21 Suppl 3, no. Suppl 3, p. e106467$$nSuppl 3$$pe106467$$tAlzheimer's and dementia$$v21$$x1552-5260$$y2025
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