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000283061 1001_ $$0P:(DE-2719)9001307$$aGrazia, Alice$$b0$$udzne
000283061 1112_ $$aAlzheimer’s Association International Conference$$cToronto$$d2025-07-27 - 2025-07-31$$gAAIC 25$$wCanada
000283061 245__ $$aPredicting longitudinal basal forebrain volume in mild cognitive impairment: the role of sex and APOE4 genotype
000283061 260__ $$c2025
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000283061 520__ $$aImaging studies showed early atrophy of the cholinergic basal forebrain already at prodromal stages of sporadic Alzheimer's disease. It is well known that women and carriers of the APOE4 allele are more likely to develop the disease, however, the mechanisms underlying the role of APOE4 in the pathogenesis of the disease as a whole and at the sex-specific level are still unknown. In this study we aim at exploring the impact of sex and APOE genotype on longitudinal measures of basal forebrain volume in mild cognitive impairment (MCI) compared to cognitively normal (CN) individuals.We analyzed MRI scans of individuals from the DELCODE study (mean age: 71 years), comprising 936 CN and 536 MCI at baseline, and 490 CN and 306 MCI at follow-up (average time:10.88 months). We performed longitudinal volume segmentation and conducted a linear mixed-effect model to calculate the effect of APOE genotype, sex, diagnosis, time and their interactions over normalized basal forebrain volume.Sex was a significant predictor of basal forebrain volume (β = -0.016, t = -3.32, p = 0.001)), with male sex and MCI diagnosis (β = -0.018, t = -6.75, p < 0.0001) being significantly associated with lower volume. However, neither APOE status (β = -0.008, t = -1.39, p = 0.165) nor time (β = -0.00002, t = -0.18, p = 0.858) had significant effects, nor did the interactions between sex, APOE status and time (Figure).Results showed that basal forebrain volume was significantly smaller in males and individuals with MCI, but the rate of change over time did not appear to differ significantly between these groups, ApoE status, or based on sex.
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000283061 650_7 $$2NLM Chemicals$$aBiomarkers
000283061 650_7 $$2NLM Chemicals$$aApolipoproteins E
000283061 650_7 $$2NLM Chemicals$$aApolipoprotein E4
000283061 650_2 $$2MeSH$$aHumans
000283061 650_2 $$2MeSH$$aMale
000283061 650_2 $$2MeSH$$aFemale
000283061 650_2 $$2MeSH$$aAged
000283061 650_2 $$2MeSH$$aCognitive Dysfunction: genetics
000283061 650_2 $$2MeSH$$aCognitive Dysfunction: pathology
000283061 650_2 $$2MeSH$$aCognitive Dysfunction: diagnostic imaging
000283061 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000283061 650_2 $$2MeSH$$aBiomarkers
000283061 650_2 $$2MeSH$$aLongitudinal Studies
000283061 650_2 $$2MeSH$$aGenotype
000283061 650_2 $$2MeSH$$aApolipoproteins E: genetics
000283061 650_2 $$2MeSH$$aApolipoprotein E4: genetics
000283061 650_2 $$2MeSH$$aBasal Forebrain: pathology
000283061 650_2 $$2MeSH$$aBasal Forebrain: diagnostic imaging
000283061 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000283061 650_2 $$2MeSH$$aSex Factors
000283061 650_2 $$2MeSH$$aMiddle Aged
000283061 650_2 $$2MeSH$$aAtrophy
000283061 7001_ $$0P:(DE-2719)2814217$$aLevin, Fedor$$b1$$udzne
000283061 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b2$$udzne
000283061 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b3$$udzne
000283061 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b4$$udzne
000283061 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b5$$udzne
000283061 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b6$$udzne
000283061 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b7$$udzne
000283061 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b8$$udzne
000283061 7001_ $$0P:(DE-2719)2811351$$aBuerger, Katharina$$b9$$udzne
000283061 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b10$$udzne
000283061 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b11$$udzne
000283061 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b12$$udzne
000283061 7001_ $$0P:(DE-2719)2812825$$aRamirez, Alfredo$$b13$$udzne
000283061 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b14$$eLast author$$udzne
000283061 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz70856_100257$$gVol. 21 Suppl 2, no. Suppl 2, p. e100257$$nSuppl 2$$pe100257$$tAlzheimer's and dementia$$v21$$x1552-5260$$y2025
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