TY  - CONF
AU  - Grazia, Alice
AU  - Levin, Fedor
AU  - Jessen, Frank
AU  - Wagner, Michael
AU  - Peters, Oliver
AU  - Priller, Josef
AU  - Schneider, Anja
AU  - Wiltfang, Jens
AU  - Düzel, Emrah
AU  - Buerger, Katharina
AU  - Perneczky, Robert
AU  - Laske, Christoph
AU  - Spottke, Annika
AU  - Ramirez, Alfredo
AU  - Teipel, Stefan
TI  - Predicting longitudinal basal forebrain volume in mild cognitive impairment: the role of sex and APOE4 genotype
JO  - Alzheimer's and dementia
VL  - 21
IS  - Suppl 2
SN  - 1552-5260
M1  - DZNE-2025-01468
SP  - e100257
PY  - 2025
AB  - Imaging studies showed early atrophy of the cholinergic basal forebrain already at prodromal stages of sporadic Alzheimer's disease. It is well known that women and carriers of the APOE4 allele are more likely to develop the disease, however, the mechanisms underlying the role of APOE4 in the pathogenesis of the disease as a whole and at the sex-specific level are still unknown. In this study we aim at exploring the impact of sex and APOE genotype on longitudinal measures of basal forebrain volume in mild cognitive impairment (MCI) compared to cognitively normal (CN) individuals.We analyzed MRI scans of individuals from the DELCODE study (mean age: 71 years), comprising 936 CN and 536 MCI at baseline, and 490 CN and 306 MCI at follow-up (average time:10.88 months). We performed longitudinal volume segmentation and conducted a linear mixed-effect model to calculate the effect of APOE genotype, sex, diagnosis, time and their interactions over normalized basal forebrain volume.Sex was a significant predictor of basal forebrain volume (β = -0.016, t = -3.32, p = 0.001)), with male sex and MCI diagnosis (β = -0.018, t = -6.75, p < 0.0001) being significantly associated with lower volume. However, neither APOE status (β = -0.008, t = -1.39, p = 0.165) nor time (β = -0.00002, t = -0.18, p = 0.858) had significant effects, nor did the interactions between sex, APOE status and time (Figure).Results showed that basal forebrain volume was significantly smaller in males and individuals with MCI, but the rate of change over time did not appear to differ significantly between these groups, ApoE status, or based on sex.
T2  - Alzheimer’s Association International Conference
CY  - 27 Jul 2025 - 31 Jul 2025, Toronto (Canada)
Y2  - 27 Jul 2025 - 31 Jul 2025
M2  - Toronto, Canada
KW  - Humans
KW  - Male
KW  - Female
KW  - Aged
KW  - Cognitive Dysfunction: genetics
KW  - Cognitive Dysfunction: pathology
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Magnetic Resonance Imaging
KW  - Biomarkers
KW  - Longitudinal Studies
KW  - Genotype
KW  - Apolipoproteins E: genetics
KW  - Apolipoprotein E4: genetics
KW  - Basal Forebrain: pathology
KW  - Basal Forebrain: diagnostic imaging
KW  - Alzheimer Disease: genetics
KW  - Sex Factors
KW  - Middle Aged
KW  - Atrophy
KW  - Biomarkers (NLM Chemicals)
KW  - Apolipoproteins E (NLM Chemicals)
KW  - Apolipoprotein E4 (NLM Chemicals)
LB  - PUB:(DE-HGF)1 ; PUB:(DE-HGF)16
C6  - pmid:41444919
C2  - pmc:PMC12738425
DO  - DOI:10.1002/alz70856_100257
UR  - https://pub.dzne.de/record/283061
ER  -