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@INPROCEEDINGS{Grazia:283061,
      author       = {Grazia, Alice and Levin, Fedor and Jessen, Frank and
                      Wagner, Michael and Peters, Oliver and Priller, Josef and
                      Schneider, Anja and Wiltfang, Jens and Düzel, Emrah and
                      Buerger, Katharina and Perneczky, Robert and Laske,
                      Christoph and Spottke, Annika and Ramirez, Alfredo and
                      Teipel, Stefan},
      title        = {{P}redicting longitudinal basal forebrain volume in mild
                      cognitive impairment: the role of sex and {APOE}4 genotype},
      journal      = {Alzheimer's and dementia},
      volume       = {21},
      number       = {Suppl 2},
      issn         = {1552-5260},
      reportid     = {DZNE-2025-01468},
      pages        = {e100257},
      year         = {2025},
      abstract     = {Imaging studies showed early atrophy of the cholinergic
                      basal forebrain already at prodromal stages of sporadic
                      Alzheimer's disease. It is well known that women and
                      carriers of the APOE4 allele are more likely to develop the
                      disease, however, the mechanisms underlying the role of
                      APOE4 in the pathogenesis of the disease as a whole and at
                      the sex-specific level are still unknown. In this study we
                      aim at exploring the impact of sex and APOE genotype on
                      longitudinal measures of basal forebrain volume in mild
                      cognitive impairment (MCI) compared to cognitively normal
                      (CN) individuals.We analyzed MRI scans of individuals from
                      the DELCODE study (mean age: 71 years), comprising 936 CN
                      and 536 MCI at baseline, and 490 CN and 306 MCI at follow-up
                      (average time:10.88 months). We performed longitudinal
                      volume segmentation and conducted a linear mixed-effect
                      model to calculate the effect of APOE genotype, sex,
                      diagnosis, time and their interactions over normalized basal
                      forebrain volume.Sex was a significant predictor of basal
                      forebrain volume (β = -0.016, t = -3.32, p = 0.001)), with
                      male sex and MCI diagnosis (β = -0.018, t = -6.75, p <
                      0.0001) being significantly associated with lower volume.
                      However, neither APOE status (β = -0.008, t = -1.39, p =
                      0.165) nor time (β = -0.00002, t = -0.18, p = 0.858) had
                      significant effects, nor did the interactions between sex,
                      APOE status and time (Figure).Results showed that basal
                      forebrain volume was significantly smaller in males and
                      individuals with MCI, but the rate of change over time did
                      not appear to differ significantly between these groups,
                      ApoE status, or based on sex.},
      month         = {Jul},
      date          = {2025-07-27},
      organization  = {Alzheimer’s Association
                       International Conference, Toronto
                       (Canada), 27 Jul 2025 - 31 Jul 2025},
      keywords     = {Humans / Male / Female / Aged / Cognitive Dysfunction:
                      genetics / Cognitive Dysfunction: pathology / Cognitive
                      Dysfunction: diagnostic imaging / Magnetic Resonance Imaging
                      / Biomarkers / Longitudinal Studies / Genotype /
                      Apolipoproteins E: genetics / Apolipoprotein E4: genetics /
                      Basal Forebrain: pathology / Basal Forebrain: diagnostic
                      imaging / Alzheimer Disease: genetics / Sex Factors / Middle
                      Aged / Atrophy / Biomarkers (NLM Chemicals) /
                      Apolipoproteins E (NLM Chemicals) / Apolipoprotein E4 (NLM
                      Chemicals)},
      cin          = {AG Teipel / AG Jessen / AG Wagner / AG Peters / AG
                      Schneider / AG Wiltfang / AG Düzel / Clinical Research
                      (Munich) / AG Dichgans / AG Gasser / AG Spottke / Patient
                      Studies (Bonn)},
      ddc          = {610},
      cid          = {I:(DE-2719)1510100 / I:(DE-2719)1011102 /
                      I:(DE-2719)1011201 / I:(DE-2719)5000000 / I:(DE-2719)1011305
                      / I:(DE-2719)1410006 / I:(DE-2719)5000006 /
                      I:(DE-2719)1111015 / I:(DE-2719)5000022 / I:(DE-2719)1210000
                      / I:(DE-2719)1011103 / I:(DE-2719)1011101},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)1 / PUB:(DE-HGF)16},
      pubmed       = {pmid:41444919},
      pmc          = {pmc:PMC12738425},
      doi          = {10.1002/alz70856_100257},
      url          = {https://pub.dzne.de/record/283061},
}