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@INPROCEEDINGS{Sannemann:283062,
      author       = {Sannemann, Lena and Buerger, Katharina and Hellmann-Regen,
                      Julian and Kleineidam, Luca and Laske, Christoph and
                      Perneczky, Robert and Peters, Oliver and Priller, Josef and
                      Ramirez, Alfredo and Schneider, Anja and Spottke, Annika and
                      Synofzik, Matthis and Teipel, Stefan J and Wagner, Michael
                      and Wiltfang, Jens and Yakupov, Renat and Düzel, Emrah and
                      Jessen, Frank},
      collaboration = {Group, DELCODE Study},
      title        = {{P}redictors of {C}ognitive {D}ecline in {I}ndividuals with
                      {S}ubjective {C}ognitive {D}ecline of the {DELCODE} {S}tudy
                      {C}ohort},
      journal      = {Alzheimer's and dementia},
      volume       = {21},
      number       = {Suppl 3},
      issn         = {1552-5260},
      reportid     = {DZNE-2025-01469},
      pages        = {e105570},
      year         = {2025},
      abstract     = {Subjective cognitive decline (SCD) refers to a
                      self-perceived, persistent cognitive decline compared to
                      previous levels in individuals with objectively unimpaired
                      cognition. Studies have repeatedly shown associations of SCD
                      characteristics with amyloid pathology and increased risk of
                      future cognitive decline, especially in memory-clinic
                      settings. The aim of this project is to model individual
                      differences of cognitive decline in individuals with
                      SCD.Latent Growth Curve Model (LGCM) analysis was applied to
                      individuals with SCD from the DZNE Longitudinal Cognitive
                      Impairment and Dementia (DELCODE) study. We chose a sample
                      of n = 203 participants who showed a decline on the
                      Preclinical Alzheimer's Cognitive Composite (PACC5) score
                      over five years. First, a two-factor linear growth model was
                      fitted on the annualized PACC5 data. We then calculated and
                      compared two models to which we added the following baseline
                      predictors: 1) plasma Aß42/40, plasma ptau181,
                      ApoE-4-carrier status and hippocampal volume (biological
                      model), and 2) Geriatric Depression Scale (GDS), Geriatric
                      Anxiety Inventory-Short Form (GAIS-SF) and Neuropsychiatric
                      Inventory Questionnaire (NPI-Q) total scores
                      (neuropsychiatric model).The LGCM of longitudinal PACC-5
                      scores yielded adequate model fit for a linear model
                      (X2(16)=67.5, p < .001, CFI = 0.93, SMRM=0.07, AIC=1437.10).
                      The baseline PACC score was -0.03 (SE = 0.05, p = .533) and
                      average cognition declined slightly over time by -0.13 (SE =
                      0.01, p < .001). The biological model showed an improvement
                      in fit, with an AIC of 742.30. Here, we observed a positive
                      relationship between plasma Aß42/40 and the intercept (B =
                      7.60, SE = 3.01, p = .012) and a negative relationship
                      between plasma ptau181 and the intercept (B = -0.22, SE =
                      0.09, p = .016). Plasma Aß42/40 was the only significant
                      predictor of the PACC5 slope in this model (B = 1.35, SE =
                      0.62, p = .030). In comparison, the AIC value for the
                      neuropsychiatric model was 1341.17, with the GDS total score
                      being negatively related to the PACC5 slope (B = -0.03, SE =
                      0.01, p = .009).These results add to gaining a better
                      understanding of SCD trajectories and specific predictors of
                      cognitive decline, which is relevant to power future
                      clinical trials in this population.},
      month         = {Jul},
      date          = {2025-07-27},
      organization  = {Alzheimer’s Association
                       International Conference, Toronto
                       (Canada), 27 Jul 2025 - 31 Jul 2025},
      keywords     = {Humans / Male / Female / Cognitive Dysfunction: blood /
                      Cognitive Dysfunction: pathology / Cognitive Dysfunction:
                      psychology / Cognitive Dysfunction: diagnosis / Cognitive
                      Dysfunction: genetics / Aged / Amyloid beta-Peptides: blood
                      / tau Proteins: blood / Neuropsychological Tests: statistics
                      $\&$ numerical data / Longitudinal Studies / Hippocampus:
                      pathology / Alzheimer Disease / Middle Aged / Peptide
                      Fragments: blood / Aged, 80 and over / Apolipoprotein E4:
                      genetics / Amyloid beta-Peptides (NLM Chemicals) / tau
                      Proteins (NLM Chemicals) / Peptide Fragments (NLM Chemicals)
                      / Apolipoprotein E4 (NLM Chemicals)},
      cin          = {AG Jessen / AG Düzel / Clinical Research (Munich) / AG
                      Endres / AG Wagner / AG Gasser / AG Dichgans / AG Peters /
                      AG Priller / Patient Studies (Bonn) / AG Spottke / AG
                      Schneider / AG Teipel / AG Wiltfang},
      ddc          = {610},
      cid          = {I:(DE-2719)1011102 / I:(DE-2719)5000006 /
                      I:(DE-2719)1111015 / I:(DE-2719)1811005 / I:(DE-2719)1011201
                      / I:(DE-2719)1210000 / I:(DE-2719)5000022 /
                      I:(DE-2719)5000000 / I:(DE-2719)5000007 / I:(DE-2719)1011101
                      / I:(DE-2719)1011103 / I:(DE-2719)1011305 /
                      I:(DE-2719)1510100 / I:(DE-2719)1410006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      experiment   = {EXP:(DE-2719)DELCODE-20140101},
      typ          = {PUB:(DE-HGF)1 / PUB:(DE-HGF)16},
      pubmed       = {pmid:41445242},
      pmc          = {pmc:PMC12739277},
      doi          = {10.1002/alz70857_105570},
      url          = {https://pub.dzne.de/record/283062},
}