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000283074 0247_ $$2ISSN$$a1552-5279
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000283074 041__ $$aEnglish
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000283074 1001_ $$0P:(DE-2719)9003305$$aGlaeser, Eva$$b0$$eFirst author$$udzne
000283074 1112_ $$aAlzheimer’s Association International Conference$$cToronto$$d2025-07-27 - 2025-07-31$$gAAIC 25$$wCanada
000283074 245__ $$aThe Economic Burden of Subjective Cognitive Decline, Mild Cognitive Impairment and Alzheimer's Dementia: Excess Costs and Associated Clinical and Risk Factors
000283074 260__ $$c2025
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000283074 520__ $$aThis study assessed costs and cost-associated factors in patients with subjective cognitive decline (SCD), mild cognitive impairment (MCI) and Alzheimer's Disease (AD) dementia compared to healthy controls.Clinical data, risk factors, healthcare resource use and informal care provision were assessed in the DELCODE study. Costs were calculated from payer and societal perspectives, with multivariate regression analyses identifying cost-associated factors.Societal costs were elevated by 50% for SCD (adjusted mean 7,705€ [95%CI 6,227-9,182€)], 199% for MCI (15,328€ [6,121-24,535€]) and 602% for AD (36,031€ [3,075-68,986€]) compared to controls (5,129€ [3,217-7,042€]). ApoE ε4 negative patients showed higher costs compared to positive patients. Hypertension was associated with higher costs, while lower education status and high cholesterol reduced costs.Healthcare costs are already significantly elevated in early subjective and objective cognitive impairment, driven by formal and informal care. The study emphasizes the importance of early interventions to reduce the economic burden and delay progression.
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000283074 650_2 $$2MeSH$$aHumans
000283074 650_2 $$2MeSH$$aMale
000283074 650_2 $$2MeSH$$aFemale
000283074 650_2 $$2MeSH$$aCognitive Dysfunction: economics
000283074 650_2 $$2MeSH$$aAlzheimer Disease: economics
000283074 650_2 $$2MeSH$$aAged
000283074 650_2 $$2MeSH$$aHealth Care Costs: statistics & numerical data
000283074 650_2 $$2MeSH$$aPublic Health: economics
000283074 650_2 $$2MeSH$$aRisk Factors
000283074 650_2 $$2MeSH$$aCost of Illness
000283074 650_2 $$2MeSH$$aAged, 80 and over
000283074 650_2 $$2MeSH$$aMiddle Aged
000283074 693__ $$0EXP:(DE-2719)DELCODE-20140101$$5EXP:(DE-2719)DELCODE-20140101$$eLongitudinal Cognitive Impairment and Dementia Study$$x0
000283074 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b1$$udzne
000283074 7001_ $$0P:(DE-2719)9001238$$aPlaten, Moritz$$b2$$udzne
000283074 7001_ $$0P:(DE-2719)2000040$$aHoffmann, Wolfgang$$b3$$udzne
000283074 7001_ $$0P:(DE-2719)2810593$$aBrosseron, Frederic$$b4$$udzne
000283074 7001_ $$0P:(DE-2719)2811351$$aBürger, Katharina$$b5$$udzne
000283074 7001_ $$0P:(DE-HGF)0$$aCoenjaerts, Marie$$b6
000283074 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b7$$udzne
000283074 7001_ $$0P:(DE-2719)9000543$$aEwers, Michael$$b8
000283074 7001_ $$0P:(DE-2719)2811326$$aFließbach, Klaus$$b9$$udzne
000283074 7001_ $$0P:(DE-2719)2810481$$aFrommann, Ingo$$b10$$udzne
000283074 7001_ $$0P:(DE-2719)9002025$$aGemenetzi, Maria$$b11$$udzne
000283074 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b12$$udzne
000283074 7001_ $$0P:(DE-2719)9003016$$aHellmann-Regen, Julian$$b13$$udzne
000283074 7001_ $$0P:(DE-2719)9001517$$aIncesoy, Enise I$$b14$$udzne
000283074 7001_ $$0P:(DE-2719)9002557$$aJanowitz, Daniel$$b15$$udzne
000283074 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b16$$udzne
000283074 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b17$$udzne
000283074 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b18$$udzne
000283074 7001_ $$0P:(DE-2719)2812825$$aRamirez, Alfredo$$b19$$udzne
000283074 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b20$$udzne
000283074 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b21$$udzne
000283074 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike Jakob$$b22$$udzne
000283074 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b23$$udzne
000283074 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b24$$udzne
000283074 7001_ $$0P:(DE-2719)2810763$$aMichalowsky, Bernhard$$b25$$eLast author$$udzne
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000283074 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz70860_100774$$gVol. 21 Suppl 6, no. Suppl 6, p. e100774$$nSuppl 6$$pe100774$$tAlzheimer's and dementia$$v21$$x1552-5260$$y2025
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