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@INPROCEEDINGS{Glaeser:283074,
      author       = {Glaeser, Eva and Kilimann, Ingo and Platen, Moritz and
                      Hoffmann, Wolfgang and Brosseron, Frederic and Bürger,
                      Katharina and Coenjaerts, Marie and Düzel, Emrah and Ewers,
                      Michael and Fließbach, Klaus and Frommann, Ingo and
                      Gemenetzi, Maria and Glanz, Wenzel and Hellmann-Regen,
                      Julian and Incesoy, Enise I and Janowitz, Daniel and Jessen,
                      Frank and Peters, Oliver and Priller, Josef and Ramirez,
                      Alfredo and Schneider, Anja and Spottke, Annika and Spruth,
                      Eike Jakob and Teipel, Stefan and Wagner, Michael and
                      Michalowsky, Bernhard},
      collaboration = {delcode},
      title        = {{T}he {E}conomic {B}urden of {S}ubjective {C}ognitive
                      {D}ecline, {M}ild {C}ognitive {I}mpairment and {A}lzheimer's
                      {D}ementia: {E}xcess {C}osts and {A}ssociated {C}linical and
                      {R}isk {F}actors},
      journal      = {Alzheimer's and dementia},
      volume       = {21},
      number       = {Suppl 6},
      issn         = {1552-5260},
      reportid     = {DZNE-2025-01481},
      pages        = {e100774},
      year         = {2025},
      abstract     = {This study assessed costs and cost-associated factors in
                      patients with subjective cognitive decline (SCD), mild
                      cognitive impairment (MCI) and Alzheimer's Disease (AD)
                      dementia compared to healthy controls.Clinical data, risk
                      factors, healthcare resource use and informal care provision
                      were assessed in the DELCODE study. Costs were calculated
                      from payer and societal perspectives, with multivariate
                      regression analyses identifying cost-associated
                      factors.Societal costs were elevated by $50\%$ for SCD
                      (adjusted mean 7,705€ $[95\%CI$ 6,227-9,182€)], $199\%$
                      for MCI (15,328€ [6,121-24,535€]) and $602\%$ for AD
                      (36,031€ [3,075-68,986€]) compared to controls (5,129€
                      [3,217-7,042€]). ApoE ε4 negative patients showed higher
                      costs compared to positive patients. Hypertension was
                      associated with higher costs, while lower education status
                      and high cholesterol reduced costs.Healthcare costs are
                      already significantly elevated in early subjective and
                      objective cognitive impairment, driven by formal and
                      informal care. The study emphasizes the importance of early
                      interventions to reduce the economic burden and delay
                      progression.},
      month         = {Jul},
      date          = {2025-07-27},
      organization  = {Alzheimer’s Association
                       International Conference, Toronto
                       (Canada), 27 Jul 2025 - 31 Jul 2025},
      keywords     = {Humans / Male / Female / Cognitive Dysfunction: economics /
                      Alzheimer Disease: economics / Aged / Health Care Costs:
                      statistics $\&$ numerical data / Public Health: economics /
                      Risk Factors / Cost of Illness / Aged, 80 and over / Middle
                      Aged},
      cin          = {AG Michalowsky / AG Hoffmann / AG Teipel / AG Wagner / AG
                      Jessen / AG Heneka / Clinical Research (Munich) / AG Düzel
                      / Patient Studies (Bonn) / AG Endres / AG Peters / AG
                      Priller / AG Schneider / AG Spottke},
      ddc          = {610},
      cid          = {I:(DE-2719)5000067 / I:(DE-2719)1510600 /
                      I:(DE-2719)1510100 / I:(DE-2719)1011201 / I:(DE-2719)1011102
                      / I:(DE-2719)1011303 / I:(DE-2719)1111015 /
                      I:(DE-2719)5000006 / I:(DE-2719)1011101 / I:(DE-2719)1811005
                      / I:(DE-2719)5000000 / I:(DE-2719)5000007 /
                      I:(DE-2719)1011305 / I:(DE-2719)1011103},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      experiment   = {EXP:(DE-2719)DELCODE-20140101},
      typ          = {PUB:(DE-HGF)1 / PUB:(DE-HGF)16},
      pubmed       = {pmid:41435114},
      pmc          = {pmc:PMC12726759},
      doi          = {10.1002/alz70860_100774},
      url          = {https://pub.dzne.de/record/283074},
}