%0 Conference Paper
%A Roehr, Susanne
%A Wittmann, Felix Georg
%A Luppa, Melanie
%A Köhler, Sebastian
%A Deckers, Kay
%A Rosenau, Colin
%A Kleineidam, Luca
%A Wagner, Michael
%A Berger, Klaus
%A Pabst, Alexander
%A Riedel-Heller, Steffi G
%T LIfestyle for BRAin health (LIBRA) and cognitive functioning from young to old adulthood: Results of the German National Cohort (NAKO)
%J Alzheimer's and dementia
%V 21 Suppl 6
%N Suppl 6
%@ 1552-5260
%M DZNE-2025-01482
%P e106257
%D 2025
%X The LIfestyle for BRAin Health (LIBRA) index is a well-validated tool for assessing modifiable dementia risk in midlife and older adults. Less is known about LIBRA in younger adults. Thus, we investigated the occurrence of LIBRA factors and associations between the LIBRA index and cognitive functioning across adulthood, spanning ages 20 to 75. We considered variations by age decade, sex, and socioeconomic status (SES).The data source was the population-based mega-cohort 'German National Cohort' (NAKO). Proportions and Cochran-Armitage trend tests were calculated for 10 out of 12 LIBRA factors (coronary heart disease, diabetes, hypercholesterolaemia, hypertension, depression, obesity, smoking, physical inactivity, chronic kidney disease, and low-to-moderate alcohol consumption; no information available on healthy diet and high cognitive activity). Cluster-adjusted (for study sites) linear regression analysis was used to assess associations of LIBRA scores and cognitive functioning (composite neuropsychological test score), adjusted for age, age2, sex, education, SES, employment status, marital status, household size, migration status, and German language proficiency, for the total and stratified samples.The analytical sample of 149,948 participants had a mean age of 50.1 (13.6) years; 50.4
%B Alzheimer’s Association International Conference
%C 27 Jul 2025 - 31 Jul 2025, Toronto (Canada)
Y2 27 Jul 2025 - 31 Jul 2025
M2 Toronto, Canada
%K Humans
%K Male
%K Female
%K Middle Aged
%K Adult
%K Aged
%K Life Style
%K Public Health
%K Risk Factors
%K Young Adult
%K Cohort Studies
%K Germany: epidemiology
%K Neuropsychological Tests
%K Dementia: epidemiology
%F PUB:(DE-HGF)1 ; PUB:(DE-HGF)16
%9 AbstractJournal Article
%$ pmid:41435134
%2 pmc:PMC12726143
%R 10.1002/alz70860_106257
%U https://pub.dzne.de/record/283075