TY  - CONF
AU  - Roehr, Susanne
AU  - Wittmann, Felix Georg
AU  - Luppa, Melanie
AU  - Köhler, Sebastian
AU  - Deckers, Kay
AU  - Rosenau, Colin
AU  - Kleineidam, Luca
AU  - Wagner, Michael
AU  - Berger, Klaus
AU  - Pabst, Alexander
AU  - Riedel-Heller, Steffi G
TI  - LIfestyle for BRAin health (LIBRA) and cognitive functioning from young to old adulthood: Results of the German National Cohort (NAKO)
JO  - Alzheimer's and dementia
VL  - 21 Suppl 6
IS  - Suppl 6
SN  - 1552-5260
M1  - DZNE-2025-01482
SP  - e106257
PY  - 2025
AB  - The LIfestyle for BRAin Health (LIBRA) index is a well-validated tool for assessing modifiable dementia risk in midlife and older adults. Less is known about LIBRA in younger adults. Thus, we investigated the occurrence of LIBRA factors and associations between the LIBRA index and cognitive functioning across adulthood, spanning ages 20 to 75. We considered variations by age decade, sex, and socioeconomic status (SES).The data source was the population-based mega-cohort 'German National Cohort' (NAKO). Proportions and Cochran-Armitage trend tests were calculated for 10 out of 12 LIBRA factors (coronary heart disease, diabetes, hypercholesterolaemia, hypertension, depression, obesity, smoking, physical inactivity, chronic kidney disease, and low-to-moderate alcohol consumption; no information available on healthy diet and high cognitive activity). Cluster-adjusted (for study sites) linear regression analysis was used to assess associations of LIBRA scores and cognitive functioning (composite neuropsychological test score), adjusted for age, age2, sex, education, SES, employment status, marital status, household size, migration status, and German language proficiency, for the total and stratified samples.The analytical sample of 149,948 participants had a mean age of 50.1 (13.6) years; 50.4
T2  - Alzheimer’s Association International Conference
CY  - 27 Jul 2025 - 31 Jul 2025, Toronto (Canada)
Y2  - 27 Jul 2025 - 31 Jul 2025
M2  - Toronto, Canada
KW  - Humans
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Adult
KW  - Aged
KW  - Life Style
KW  - Public Health
KW  - Risk Factors
KW  - Young Adult
KW  - Cohort Studies
KW  - Germany: epidemiology
KW  - Neuropsychological Tests
KW  - Dementia: epidemiology
LB  - PUB:(DE-HGF)1 ; PUB:(DE-HGF)16
C6  - pmid:41435134
C2  - pmc:PMC12726143
DO  - DOI:10.1002/alz70860_106257
UR  - https://pub.dzne.de/record/283075
ER  -