% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@INPROCEEDINGS{Blotenberg:283078,
      author       = {Blotenberg, Iris and Wittström, Felix and Michalowsky,
                      Bernhard and Platen, Moritz and Wucherer, Diana and Teipel,
                      Stefan and Hoffmann, Wolfgang and Thyrian, Jochen René},
      title        = {{M}odifiable factors predict symptom progression in
                      dementia over eight years},
      journal      = {Alzheimer's and dementia},
      volume       = {21},
      number       = {Suppl 6},
      issn         = {1552-5260},
      reportid     = {DZNE-2025-01485},
      pages        = {e097492},
      year         = {2025},
      abstract     = {The aim of the present study was to investigate the
                      association between modifiable factors and symptom
                      progression in people with dementia over a period of up to
                      eight years.We used data from a German cohort of
                      community-dwelling individuals who screened positive for
                      dementia in primary care. They underwent comprehensive
                      annual in-home-assessments for up to eight years by
                      specially trained nurses. The following modifiable factors
                      were considered: low education, hearing impairment (and its
                      treatment), hypertension (and its treatment), alcohol
                      consumption, obesity, smoking, depression, social isolation,
                      physical inactivity, diabetes (and its treatment) and visual
                      impairment. We used multilevel growth curve models to
                      investigate the role of modifiable risk factors on cognitive
                      trajectories and trajectories in daily functioning.Higher
                      education was associated with higher cognitive status at the
                      beginning of the study, but also with faster cognitive
                      decline over time. People receiving anti-diabetic
                      medications showed slower cognitive decline, while
                      depression and visual impairment were associated with lower
                      levels of daily functioning at baseline and faster cognitive
                      decline over the eight-year study period. We found no
                      association of hearing impairment (or its treatment),
                      hypertension (or its treatment), alcohol consumption,
                      obesity, smoking, lack of social support and physical
                      inactivity with the rate of symptom progression.Our study
                      found evidence that several potentially modifiable risk
                      factors influenced symptom progression in dementia over up
                      to eight years. Cognitive reserve through education showed a
                      positive effect, which reversed over time, and depressive
                      symptoms were linked to less favorable progression. Treating
                      comorbidities like diabetes and visual impairment may
                      positively impact dementia symptoms. Modifiable risk factors
                      are promising targets for tertiary prevention and should be
                      explored further.},
      month         = {Jul},
      date          = {2025-07-27},
      organization  = {Alzheimer’s Association
                       International Conference, Toronto
                       (Canada), 27 Jul 2025 - 31 Jul 2025},
      keywords     = {Humans / Male / Female / Aged / Dementia: epidemiology /
                      Risk Factors / Germany: epidemiology / Disease Progression /
                      Public Health / Aged, 80 and over / Cognitive Dysfunction:
                      epidemiology / Cohort Studies},
      cin          = {AG Thyrian / AG Michalowsky / AG Teipel / AG Hoffmann},
      ddc          = {610},
      cid          = {I:(DE-2719)1510800 / I:(DE-2719)5000067 /
                      I:(DE-2719)1510100 / I:(DE-2719)1510600},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)1 / PUB:(DE-HGF)16},
      pubmed       = {pmid:41435243},
      pmc          = {pmc:PMC12726345},
      doi          = {10.1002/alz70860_097492},
      url          = {https://pub.dzne.de/record/283078},
}