%0 Conference Paper
%A Platen, Moritz
%A Buchholz, Maresa
%A Raedke, Anika
%A Scharf, Annelie
%A Glaeser, Eva
%A Iskandar, Audrey
%A Hoffmann, Wolfgang
%A Michalowsky, Bernhard
%T Differentiation between early and severe stages of dementia using diagnosis, prescription and utilization patterns
%J Alzheimer's and dementia
%V 21
%N S6
%@ 1552-5260
%M DZNE-2025-01489
%P e100898
%D 2025
%X Background:Routinely collected claims data often lack clinical parameters like dementia severity, which are essential for treatments targeting early disease stages. Diagnoses, prescriptions, and healthcare service utilization patterns are commonly used to infer dementia severity, but evidence validating these patterns is limited.Objective:To identify and validate predictors (diagnoses, prescriptions, and utilization patterns) for differentiating early and more severe dementia stages.Methods:This cross-sectional analysis used baseline data from 737 dementia patients. Comprehensive assessments captured clinical data and healthcare utilization. Diagnoses and prescribed medications were extracted from general practitioner files. Dementia severity was categorized by the Mini-Mental State Examination (MMSE): early (≥27), mild (20–26), and moderate/severe (0–19). Ordinal logistic regression analyzed associations between predictors and severity, with average marginal effects (AME) quantifying their impact. Specificity and negative predictive values (NPV) were calculated to exclude milder stages.Results:The sample (56
%B Alzheimer’s Association International Conference
%C 27 Jul 2025 - 31 Jul 2025, Toronto (Canada)
Y2 27 Jul 2025 - 31 Jul 2025
M2 Toronto, Canada
%F PUB:(DE-HGF)1 ; PUB:(DE-HGF)16
%9 AbstractJournal Article
%R 10.1002/alz70860_100898
%U https://pub.dzne.de/record/283082