TY  - CONF
AU  - Platen, Moritz
AU  - Buchholz, Maresa
AU  - Raedke, Anika
AU  - Scharf, Annelie
AU  - Glaeser, Eva
AU  - Iskandar, Audrey
AU  - Hoffmann, Wolfgang
AU  - Michalowsky, Bernhard
TI  - Differentiation between early and severe stages of dementia using diagnosis, prescription and utilization patterns
JO  - Alzheimer's and dementia
VL  - 21
IS  - S6
SN  - 1552-5260
M1  - DZNE-2025-01489
SP  - e100898
PY  - 2025
AB  - Background:Routinely collected claims data often lack clinical parameters like dementia severity, which are essential for treatments targeting early disease stages. Diagnoses, prescriptions, and healthcare service utilization patterns are commonly used to infer dementia severity, but evidence validating these patterns is limited.Objective:To identify and validate predictors (diagnoses, prescriptions, and utilization patterns) for differentiating early and more severe dementia stages.Methods:This cross-sectional analysis used baseline data from 737 dementia patients. Comprehensive assessments captured clinical data and healthcare utilization. Diagnoses and prescribed medications were extracted from general practitioner files. Dementia severity was categorized by the Mini-Mental State Examination (MMSE): early (≥27), mild (20–26), and moderate/severe (0–19). Ordinal logistic regression analyzed associations between predictors and severity, with average marginal effects (AME) quantifying their impact. Specificity and negative predictive values (NPV) were calculated to exclude milder stages.Results:The sample (56
T2  - Alzheimer’s Association International Conference
CY  - 27 Jul 2025 - 31 Jul 2025, Toronto (Canada)
Y2  - 27 Jul 2025 - 31 Jul 2025
M2  - Toronto, Canada
LB  - PUB:(DE-HGF)1 ; PUB:(DE-HGF)16
DO  - DOI:10.1002/alz70860_100898
UR  - https://pub.dzne.de/record/283082
ER  -