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@INPROCEEDINGS{Polk:283092,
      author       = {Polk, Sarah E and Clark, Lindsay R and Basche, Kristin E
                      and Kleineidam, Luca and Glanz, Wenzel and Butryn, Michaela
                      and Perneczky, Robert and Buerger, Katharina and Fliessbach,
                      Klaus and Laske, Christoph and Spottke, Annika and
                      Schneider, Anja and Wiltfang, Jens and Teipel, Stefan J and
                      Wagner, Michael and Johnson, Sterling C and Jessen, Frank
                      and Düzel, Emrah and Berron, David},
      title        = {{R}emote and unsupervised monitoring of episodic memory
                      decline in patients with prodromal {A}lzheimer's disease},
      journal      = {Alzheimer's and dementia},
      volume       = {21},
      number       = {Suppl 9},
      issn         = {1552-5260},
      reportid     = {DZNE-2025-01499},
      pages        = {e110650},
      year         = {2025},
      abstract     = {Traditional pen-and-paper neuropsychological assessments
                      are not sensitive to subtle cognitive changes in the
                      earliest stages of Alzheimer's disease (AD), limiting their
                      use for monitoring of cognitive performance over shorter
                      timeframes. Here, we show that frequently administered
                      remote and unsupervised digital cognitive assessments are
                      better suited to capture short-term cognitive decline in
                      early AD.We investigated episodic memory trajectories using
                      self-administered remote digital testing in 202 participants
                      (52-85 years) who completed unsupervised tests for at least
                      30 weeks. Linear mixed modeling was used to investigate main
                      effects of cognitive status, n = 152 cognitively unimpaired
                      (CU), n = 50 with mild cognitive impairment (MCI), and
                      interaction effects of cognitive status by time spent in the
                      study. Analyses were repeated, stratifying the MCI group by
                      amyloid-β (Aβ) burden (n Aβ- = 21, n Aβ+ = 24). Baseline
                      and change-change associations with in-person
                      neuropsychological assessments were also examined using
                      Pearson correlations.At baseline, MCI performed worse than
                      CU on an associative memory task (Object-in-Room Recall,
                      ORR), memory precision tasks for objects and scenes
                      (Mnemonic Discrimination Task for Objects and Scenes,
                      MDT-OS), and a familiarity-based memory task (Complex Scene
                      Recognition, CSR). A short-term decline in the
                      familiarity-dependent task was observed in all patients with
                      an MCI diagnosis, while both the familiarity-dependent
                      memory task and memory precision for objects task were
                      sensitive to decline in the MCI Aβ+ group specifically.
                      Change in the remotely assessed familiarity-dependent memory
                      was correlated with multi-year change on annual in-person
                      neuropsychological assessments. Finally, in-person tests
                      were not sensitive to short-term cognitive changes in
                      MCI.Altogether, these findings show that frequent remote
                      cognitive testing is a promising tool to feasibly capture
                      subtle and short-term cognitive decline.},
      month         = {Jul},
      date          = {2025-07-27},
      organization  = {Alzheimer’s Association
                       International Conference, Toronto
                       (Canada), 27 Jul 2025 - 31 Jul 2025},
      keywords     = {Humans / Male / Female / Neuropsychological Tests / Aged /
                      Cognitive Dysfunction: diagnosis / Cognitive Dysfunction:
                      psychology / Middle Aged / Aged, 80 and over / Memory,
                      Episodic / Alzheimer Disease: diagnosis / Dementia:
                      diagnosis},
      cin          = {AG Berron / AG Wagner / AG Düzel / AG Teipel / AG Jessen /
                      AG Dichgans / Clinical Research (Munich) / Patient Studies
                      (Bonn) / AG Gasser / AG Spottke / AG Schneider / AG
                      Wiltfang},
      ddc          = {610},
      cid          = {I:(DE-2719)5000070 / I:(DE-2719)1011201 /
                      I:(DE-2719)5000006 / I:(DE-2719)1510100 / I:(DE-2719)1011102
                      / I:(DE-2719)5000022 / I:(DE-2719)1111015 /
                      I:(DE-2719)1011101 / I:(DE-2719)1210000 / I:(DE-2719)1011103
                      / I:(DE-2719)1011305 / I:(DE-2719)1410006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)1 / PUB:(DE-HGF)16},
      pubmed       = {pmid:41433252},
      pmc          = {pmc:PMC12725082},
      doi          = {10.1002/alz70863_110650},
      url          = {https://pub.dzne.de/record/283092},
}