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@INPROCEEDINGS{Marquardt:283093,
      author       = {Marquardt, Jonas and Vockert, Niklas and Behrenbruch,
                      Niklas and Schumann-Werner, Beate and Hochkeppler, Anne and
                      Buechel, Anna-Therese and Molloy, Eóin N. and Schwarck,
                      Svenja and Fischer, Larissa and Incesoy, Enise I and
                      Garcia-Garcia, Berta and Mattern, Hendrik and Marcos
                      Morgado, Barbara and Esselmann, Hermann and Stephens, Andrew
                      W and Schildan, Andreas and Barthel, Henryk and Sabri, Osama
                      and Wiltfang, Jens and Kreissl, Michael C and Düzel, Emrah
                      and Kuehn, Esther and Schreiber, Stefanie and Maass, Anne
                      and Diersch, Nadine},
      title        = {{H}ippocampal vascularization is associated with greater
                      efficiency during a remote real world wayfinding training in
                      older adults},
      journal      = {Alzheimer's and dementia},
      volume       = {21},
      number       = {Suppl 9},
      issn         = {1552-5260},
      reportid     = {DZNE-2025-01500},
      pages        = {e110578},
      year         = {2025},
      abstract     = {Alzheimer's Disease (AD) pathology accumulates early in the
                      medial temporal lobe (MTL), crucial for spatial navigation.
                      As spatial navigation is among the first cognitive functions
                      affected by AD, it may benefit from targeted behavioral
                      interventions. We investigated the potential of a novel
                      smartphone-assisted real-world wayfinding training, tailored
                      for healthy older adults, to improve their spatial abilities
                      and explored associations with hippocampal vascularization
                      and AD biomarkers.38 cognitively healthy older adults (62-84
                      years; 18 females) participated in a 3-week navigation
                      training, using our smartphone application 'Explore' (Figure
                      1). Training involved finding several locations displayed on
                      a map in the medical campus area of Magdeburg, Germany,
                      while GPS data were recorded. Pre- and post-training,
                      participants underwent fMRI, performed a pointing task in a
                      virtual campus version, and completed the VWLT. At
                      pre-assessment, AD pathology was characterized by plasma
                      sampling (Abeta1-42/1-40, Ptau217) and [18F]PI-2620 PET in a
                      subsample. Hippocampal vascularization was assessed by 7T
                      angiography. Performance in the virtual pointing task and a
                      map drawing test was compared to a control group (n = 20)
                      who performed a walking task of equal length without a
                      navigational component. Additionally, changes in different
                      mobile wayfinding performance indicators and their
                      associations with AD biomarkers and hippocampal
                      vascularization (i.e., mean distance of hippocampus to
                      surrounding vessels) were examined.Performance in the
                      pointing task and map drawing, but not in the VWLT (p =
                      .321), significantly improved due to the training (all p
                      <.001; Figure 2A C). The control group showed no
                      improvements in navigation. Training benefits were also
                      evident in the mobile data (all p ≤.017; Figure 3A-E).
                      Better wayfinding efficiency was associated with less vessel
                      distance to hippocampus, r=.44, p = .012, and the number of
                      orientation stops was negatively related to pTau217, r=-.38,
                      p = .019 (Figure 3F).We provide evidence that a remotely
                      administered real-world wayfinding training enhances
                      wayfinding abilities and improves spatial memory in older
                      adults. Importantly, hippocampal vascularization may benefit
                      wayfinding efficiency. Higher pTau217 was related to fewer
                      orientation stops during navigation. As a next step,
                      potential mediating effects between vascularization and AD
                      pathology on wayfinding performance will be investigated.},
      month         = {Jul},
      date          = {2025-07-27},
      organization  = {Alzheimer’s Association
                       International Conference, Toronto
                       (Canada), 27 Jul 2025 - 31 Jul 2025},
      keywords     = {Humans / Female / Aged / Male / Hippocampus: diagnostic
                      imaging / Hippocampus: blood supply / Aged, 80 and over /
                      Middle Aged / Magnetic Resonance Imaging / Alzheimer Disease
                      / Spatial Navigation: physiology / Smartphone / Amyloid
                      beta-Peptides: blood / Positron-Emission Tomography /
                      Biomarkers: blood / Mobile Applications / Dementia /
                      Neuropsychological Tests / Amyloid beta-Peptides (NLM
                      Chemicals) / Biomarkers (NLM Chemicals)},
      cin          = {AG Maaß / AG Düzel / AG Schreiber / AG Wiltfang / Core MR
                      PET / AG Gasser},
      ddc          = {610},
      cid          = {I:(DE-2719)1311001 / I:(DE-2719)5000006 /
                      I:(DE-2719)1310010 / I:(DE-2719)1410006 / I:(DE-2719)1340016
                      / I:(DE-2719)1210000},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)1 / PUB:(DE-HGF)16},
      pubmed       = {pmid:41433357},
      pmc          = {pmc:PMC12725357},
      doi          = {10.1002/alz70863_110578},
      url          = {https://pub.dzne.de/record/283093},
}