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@INPROCEEDINGS{Kindler:283096,
      author       = {Kindler, Christine and Gillis, Grace and Bhalerao, Gaurav V
                      and Andersson, Jesper L R and McCarthy, Paul and Miklitz,
                      Carolin and Stoecker, Tony and Petzold, Gabor C and
                      Griffanti, Ludovica},
      title        = {{N}ucleus {B}asalis of {M}eynert: {F}unctional
                      {C}onnectivity and {M}orphometry in {A}lzheimer’s
                      {D}isease and {F}rontotemporal {D}ementia},
      journal      = {Alzheimer's and dementia},
      volume       = {21},
      number       = {Suppl 8},
      issn         = {1552-5260},
      reportid     = {DZNE-2025-01503},
      pages        = {e110164},
      year         = {2025},
      abstract     = {The nucleus basalis of Meynert (NBM) is crucial for
                      learning, attention, and memory. While its involvement in
                      Alzheimer's disease (AD) has been widely reported, the role
                      in frontotemporal dementia (FTD) remains unclear. Here we
                      examined NBM functional connectivity (FC) as well as NBM and
                      cortical volume changes in AD, healthy controls (HC), and
                      FTD subtypes: behavioral variant FTD (bvFTD), unclassified
                      primary progressive aphasia (PPA), progressive nonfluent
                      aphasia (PNFA), semantic dementia (SemD), and progressive
                      logopenic aphasia (PLA).Resting-state fMRI and T1-weighted
                      scans were collected from HC (n = 66), individuals with AD
                      (n = 50), bvFTD (n = 63), PLA (n = 18), PPA (n = 20), PNFA
                      (n = 32), and SemD (n = 15). We performed seed-based FC
                      analyses in FSL with left and right NBM as seeds. We
                      compared HC with AD (cluster-based threshold z > 2.3, p <
                      0.05). Significant clusters were used to extract mean FC for
                      the other groups. We then compared FC values and normalized
                      NBM volumes across HC and FTD subtypes using the
                      Kruskal-Wallis test, followed by Bonferroni-corrected
                      pairwise comparisons where applicable. Voxel-based
                      morphometry (VBM) was conducted to explore cortical atrophy
                      patterns.HC showed stronger NBM connectivity than AD in the
                      hippocampus/parahippocampal gyrus, frontal pole,
                      paracingulate cortex, precuneus, and lateral occipital
                      cortex (Figure 1, left NBM results). Across HC and FTD
                      subtypes, we found significant group differences for the
                      paracingulate (H = 36.15, p < 0.001) and lateral occipital
                      cortex (H = 18.25, p = 0.003). Connectivity was higher in
                      bvFTD, PPA, and LPA than in HC, with the strongest effect
                      for bvFTD in the paracingulate cortex (r = 0.48) and
                      moderate effects across other contrasts (r = 0.28-0.42, all
                      p < 0.020). Volumetric analyses indicated no significant
                      group differences in NBM volumes but distinct cortical
                      atrophy patterns: PNFA, PLA, and PPA exhibited temporal-
                      frontal atrophy similar to AD, while bvFTD showed
                      predominantly frontal and SemD primarily temporal
                      atrophy.Differential functional connectivity of the NBM and
                      distinct cortical atrophy patterns were observed between HC
                      and AD and between HC and FTD subtypes. Ongoing analyses on
                      subgroup comparisons and integration of cognitive
                      assessments aim to elucidate these relationships and their
                      clinical implications.},
      month         = {Jul},
      date          = {2025-07-27},
      organization  = {Alzheimer’s Association
                       International Conference, Toronto
                       (Canada), 27 Jul 2025 - 31 Jul 2025},
      keywords     = {Humans / Alzheimer Disease: diagnostic imaging / Alzheimer
                      Disease: pathology / Alzheimer Disease: physiopathology /
                      Male / Female / Magnetic Resonance Imaging / Aged /
                      Frontotemporal Dementia: diagnostic imaging / Frontotemporal
                      Dementia: pathology / Frontotemporal Dementia:
                      physiopathology / Middle Aged / Basal Nucleus of Meynert:
                      diagnostic imaging / Basal Nucleus of Meynert: pathology /
                      Basal Nucleus of Meynert: physiopathology / Aphasia, Primary
                      Progressive},
      cin          = {Patient Studies (Bonn) / AG Stöcker / AG Petzold},
      ddc          = {610},
      cid          = {I:(DE-2719)1011101 / I:(DE-2719)1013026 /
                      I:(DE-2719)1013020},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 354 -
                      Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)1 / PUB:(DE-HGF)16},
      pubmed       = {pmid:41433522},
      pmc          = {pmc:PMC12725497},
      doi          = {10.1002/alz70862_110164},
      url          = {https://pub.dzne.de/record/283096},
}