%0 Conference Paper
%A Behrenbruch, Niklas
%A Schwarck, Svenja
%A Schumann-Werner, Beate
%A Molloy, Eóin N.
%A Hochkeppler, Anne
%A Buechel, Anna-Therese
%A Moyano, Jose Bernal
%A Incesoy, Enise I
%A Garcia-Garcia, Berta
%A Vockert, Niklas
%A Marcos Morgado, Barbara
%A Fischer, Larissa
%A Müller, Patrick
%A Behnisch, Gusalija
%A Seidenbecher, Constanze I
%A Schott, Björn H
%A Esselmann, Hermann
%A Wiltfang, Jens
%A Barthel, Henryk
%A Sabri, Osama
%A Kreissl, Michael C
%A Düzel, Emrah
%A Maass, Anne
%T Lifestyle and health signatures of brain pathological and cognitive aging
%J Alzheimer's and dementia
%V 21
%N Suppl 8
%@ 1552-5260
%M DZNE-2025-01504
%P e109741
%D 2025
%X While aging almost inevitably leads to some degree of cognitive decline, the interindividual heterogeneity in the trajectories of decline raises the question of the extent to which resistance against pathology and cognitive resilience are involved. Using a multimodal approach including neuroimaging, fitness assessment, questionnaire data, and Alzheimer's disease (AD) genetic risk and plasma biomarkers (Figure 1), we aimed to characterize latent structures of lifestyle, mental and bodily health, estimate indices of brain (pathological) and cognitive aging, and relate lifestyle/health profiles and AD genetic risk to these indices.We analyzed a subsample of 211 cognitively normal older adults aged ≥ 60 years from an ongoing study (CRC1436) (age=71.0±7.4years, 46
%B Alzheimer’s Association International Conference
%C 27 Jul 2025 - 31 Jul 2025, Toronto (Canada)
Y2 27 Jul 2025 - 31 Jul 2025
M2 Toronto, Canada
%K Humans
%K Female
%K Aged
%K Male
%K Alzheimer Disease: genetics
%K Alzheimer Disease: pathology
%K Alzheimer Disease: diagnostic imaging
%K Brain: pathology
%K Brain: diagnostic imaging
%K Middle Aged
%K Life Style
%K Magnetic Resonance Imaging
%K Aging: pathology
%K Principal Component Analysis
%K Aged, 80 and over
%K Neuroimaging
%K Biomarkers: blood
%K Biomarkers (NLM Chemicals)
%F PUB:(DE-HGF)1 ; PUB:(DE-HGF)16
%9 AbstractJournal Article
%$ pmid:41433525
%2 pmc:PMC12724826
%R 10.1002/alz70862_109741
%U https://pub.dzne.de/record/283097