TY  - CONF
AU  - Behrenbruch, Niklas
AU  - Schwarck, Svenja
AU  - Schumann-Werner, Beate
AU  - Molloy, Eóin N.
AU  - Hochkeppler, Anne
AU  - Buechel, Anna-Therese
AU  - Moyano, Jose Bernal
AU  - Incesoy, Enise I
AU  - Garcia-Garcia, Berta
AU  - Vockert, Niklas
AU  - Marcos Morgado, Barbara
AU  - Fischer, Larissa
AU  - Müller, Patrick
AU  - Behnisch, Gusalija
AU  - Seidenbecher, Constanze I
AU  - Schott, Björn H
AU  - Esselmann, Hermann
AU  - Wiltfang, Jens
AU  - Barthel, Henryk
AU  - Sabri, Osama
AU  - Kreissl, Michael C
AU  - Düzel, Emrah
AU  - Maass, Anne
TI  - Lifestyle and health signatures of brain pathological and cognitive aging
JO  - Alzheimer's and dementia
VL  - 21
IS  - Suppl 8
SN  - 1552-5260
M1  - DZNE-2025-01504
SP  - e109741
PY  - 2025
AB  - While aging almost inevitably leads to some degree of cognitive decline, the interindividual heterogeneity in the trajectories of decline raises the question of the extent to which resistance against pathology and cognitive resilience are involved. Using a multimodal approach including neuroimaging, fitness assessment, questionnaire data, and Alzheimer's disease (AD) genetic risk and plasma biomarkers (Figure 1), we aimed to characterize latent structures of lifestyle, mental and bodily health, estimate indices of brain (pathological) and cognitive aging, and relate lifestyle/health profiles and AD genetic risk to these indices.We analyzed a subsample of 211 cognitively normal older adults aged ≥ 60 years from an ongoing study (CRC1436) (age=71.0±7.4years, 46
T2  - Alzheimer’s Association International Conference
CY  - 27 Jul 2025 - 31 Jul 2025, Toronto (Canada)
Y2  - 27 Jul 2025 - 31 Jul 2025
M2  - Toronto, Canada
KW  - Humans
KW  - Female
KW  - Aged
KW  - Male
KW  - Alzheimer Disease: genetics
KW  - Alzheimer Disease: pathology
KW  - Alzheimer Disease: diagnostic imaging
KW  - Brain: pathology
KW  - Brain: diagnostic imaging
KW  - Middle Aged
KW  - Life Style
KW  - Magnetic Resonance Imaging
KW  - Aging: pathology
KW  - Principal Component Analysis
KW  - Aged, 80 and over
KW  - Neuroimaging
KW  - Biomarkers: blood
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)1 ; PUB:(DE-HGF)16
C6  - pmid:41433525
C2  - pmc:PMC12724826
DO  - DOI:10.1002/alz70862_109741
UR  - https://pub.dzne.de/record/283097
ER  -