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| 001 | 283100 | ||
| 005 | 20260217130202.0 | ||
| 024 | 7 | _ | |2 pmc |a pmc:PMC12731685 |
| 024 | 7 | _ | |2 doi |a 10.3390/diagnostics15243244 |
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| 041 | _ | _ | |a English |
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| 100 | 1 | _ | |0 P:(DE-2719)9003165 |a Bendella, Zeynep |b 0 |e First author |u dzne |
| 245 | _ | _ | |a Longitudinal Monitoring of Brain Volume Changes After COVID-19 Infection Using Artificial Intelligence-Based MRI Volumetry. |
| 260 | _ | _ | |a Basel |b MDPI |c 2025 |
| 336 | 7 | _ | |2 DRIVER |a article |
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| 336 | 7 | _ | |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |a Journal Article |b journal |m journal |s 1767101377_6288 |
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| 520 | _ | _ | |a Background/Objectives: SARS-CoV-2 infection has been linked to long-term neurological sequelae and structural brain alterations. Previous analyses, including baseline results from the COVIMMUNE-Clin study, showed brain volume reductions in COVID-19 patients. Longitudinal data on progression are scarce. This study examined brain volume changes 12 months after baseline MRI in individuals who have recovered from mild or severe COVID-19 compared with controls. Methods: In this IRB-approved cohort study, 112 out of 172 recruited age- and sex-matched participants (38 controls, 36 mild/asymptomatic 38 severe COVID-19) underwent standardized brain MRI 12 months after baseline. Volumetric analysis was performed using AI-based software (mdbrain). Regional volumes were compared between groups with respect to absolute and normalized values. Multivariate regression controlled for demographics. Results: After 12 months, a significant decline in right hippocampal volume was observed across all groups, most pronounced in severe COVID-19 (SEV: Δ = -0.32 mL, p = 0.001). Normalized to intracranial volume, the reduction remained significant (SEV: Δ = -0.0003, p = 0.001; ASY: Δ = -0.0001, p = 0.001; CTL: minimal reduction, Δ ≈ 0, p = 0.005). Minor reductions in frontal and parietal lobes (e.g., right frontal SEV: Δ = -1.35 mL, p = 0.001), largely fell within physiological norms. These mild regional changes are consistent with expected ageing-related variability and do not suggest pathological progression. No widespread progressive atrophy was detected. Conclusions: This study demonstrates delayed, severity-dependent right hippocampal atrophy in recovered COVID-19 patients, suggesting long-term vulnerability of this memory-related region. In contrast, no progression of atrophy in other areas was observed. These findings highlight the need for extended post-COVID neurological monitoring, particularly of hippocampal integrity and its cognitive relevance. |
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| 650 | _ | 7 | |2 Other |a COVID-19 |
| 650 | _ | 7 | |2 Other |a SARS-CoV-2 |
| 650 | _ | 7 | |2 Other |a artificial intelligence |
| 650 | _ | 7 | |2 Other |a brain atrophy |
| 650 | _ | 7 | |2 Other |a hippocampal volume |
| 650 | _ | 7 | |2 Other |a magnetic resonance imaging |
| 700 | 1 | _ | |0 P:(DE-2719)2810687 |a Widmann, Catherine Nichols |b 1 |
| 700 | 1 | _ | |0 P:(DE-2719)9000373 |a Kindler, Christine |b 2 |u dzne |
| 700 | 1 | _ | |0 P:(DE-2719)9001860 |a Haase, Robert |b 3 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Sauer, Malte |b 4 |
| 700 | 1 | _ | |0 P:(DE-2719)2000008 |a Heneka, Michael |b 5 |
| 700 | 1 | _ | |0 P:(DE-2719)9001861 |a Radbruch, Alexander |b 6 |u dzne |
| 700 | 1 | _ | |0 P:(DE-2719)9001551 |a Schmeel, Frederic Carsten |b 7 |e Last author |
| 770 | _ | _ | |a Advancing Clinical Diagnosis with Artificial Intelligence: Applications, Challenges, and Future Directions |
| 773 | _ | _ | |0 PERI:(DE-600)2662336-5 |a 10.3390/diagnostics15243244 |g Vol. 15, no. 24, p. 3244 - |n 24 |p 3244 |t Diagnostics |v 15 |x 2075-4418 |y 2025 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/283100/files/DZNE-2025-1507.pdf |y OpenAccess |
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